止咳祛痰汤联合盐酸氨溴索治疗支原体肺炎临床研究  

Clinical Study on Zhike Qutan Tang Combined with Ambroxol Hydrochloride for Mycoplasma Pneumonia

作　　者：李慧娇[1] 王一萍[1] 何薇[1] 尤志新 LI Huijiao;WANG Yiping;HE Wei;YOU Zhixin

机构地区：[1]绍兴市中医院呼吸科,浙江绍兴312000

出　　处：《新中医》2022年第7期81-84,共4页New Chinese Medicine

摘　　要：目的:观察止咳祛痰汤联合盐酸氨溴索治疗支原体肺炎的临床疗效。方法:选取40例支原体肺炎患者,按随机数字表法分为对照组和观察组各20例。2组均给予常规基础与对症治疗,对照组给予盐酸氨溴索注射液静脉滴注,观察组在对照组基础上加用止咳祛痰汤治疗。比较2组临床症状消退时间、住院时间,检测血清可溶性B7同源体3 (sB7-H3)水平,评价临床疗效及不良反应发生情况。结果:观察组总有效率为95.00%,高于对照组70.00%,差异有统计学意义(P<0.05)。观察组发热消退时间、肺啰音消失时间、咳嗽消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,2组sB7-H3水平比较,差异无统计学意义(P>0.05)。治疗1个疗程、2个疗程后,2组sB7-H3水平逐渐降低,且观察组sB7-H3水平均低于同时间点对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:止咳祛痰汤联合盐酸氨溴索治疗支原体肺炎疗效较好,可以改善患者临床症状,降低sB7-H3水平。Objective: To observe the clinical effect of Zhike Qutan tang combined with ambroxol hydrochloride for mycoplasma pneumonia. Methods:A total of 40 cases of patients with mycoplasma pneumonia were selected and divided into the control group and the observation group according to the random number table method,with 20 cases in each group.Both groups were given routine basic and symptomatic treatment;the control group was given intravenous infusion with ambroxol hydrochloride injection, and the observation group was additionally treated with Zhike Qutan tang based on the treatment of the control group. The disappearance time of clinical symptoms and hospitalization time in the two groups were compared;the levels of soluble B7 homologous 3(sB7-H3) in serum were detected;the clinical effects and the incidences of adverse reactions were evaluated. Results:The total effective rate was 95.00% in the observation group,higher than that of 70.00% in the control group,the difference being significant(P<0.05). The antipyretic time,the disappearance time of lung rales and coughing,and hospitalization time in the observation group were shorter than those in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of sB7-H3 levels between the two groups(P>0.05). After one course of treatment and two courses of treatment respectively,sB7-H3 levels in the two groups were gradually decreased,and the level in the observation group was lower than that in the control group at the same time point,differences being significant(P<0.05). There was no significant difference being found in the comparison of incidences of adverse reactions between the two groups(P>0.05). Conclusion:The therapy of Zhike Qutan tang combined with ambroxol hydrochloride for mycoplasma pneumonia has a good curative effect,and can improve the clinical symptoms and reduce sB7-H3 levels.

关 键 词：支原体肺炎 止咳祛痰汤 盐酸氨溴索 可溶性B7同源体3 症状消失时间 住院时间 

分 类 号：R563.1[医药卫生—呼吸系统]