安神平衡针刺法联合艾司唑仑片治疗慢性失眠症疗效观察及对过度觉醒状态、血清神经递质水平的影响  

Curative Effect of Anshen Pingheng Acupuncture Method Combined with Estazolam Tablets for Chronic Insomnia and Its Effect on Hyperarousal State and Serum Neurotransmitter Levels

作　　者：任志欣[1] 朱敬云[1] 王琳琳[1] 邵素菊[2] REN Zhixin;ZHU Jingyun;WANG Linlin;SHAO Suju

机构地区：[1]郑州大学第二附属医院针灸理疗科,河南郑州450000 [2]河南中医药大学第三附属医院针灸科,河南郑州450000

出　　处：《新中医》2022年第7期200-204,共5页New Chinese Medicine

基　　金：河南省中医药科学研究专项课题(2015ZYO2056)。

摘　　要：目的:观察安神平衡针刺法联合艾司唑仑片治疗慢性失眠症的疗效及对血清神经递质水平、过度觉醒状态的影响。方法:选取112例慢性失眠症患者作为研究对象,按随机数字表法分为对照组及观察组各56例,对照组脱落3例,观察组脱落2例。对照组给予口服艾司唑仑片,观察组在对照组基础上联合安神平衡针刺法治疗。2组共治疗3周。比较2组治疗前后过度觉醒状态[过度觉醒量表(HAS)、入睡前觉醒量表(PSAS)]、相关神经电生理学效应[睡眠总时间(TST)、睡眠潜伏期(SOL)、觉醒次数(NWAK)、非快速眼动1/2/3期(1/2/3,N1、N2、N3)与快速眼动睡眠期(REM)占TST比例]及血清神经递质[血清γ-氨基丁酸(GABA)含量、谷氨酸(GA)]水平的变化。结果:治疗后,2组HAS评分、PSAS评分均较治疗前下降,观察组HAS评分、PSAS评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组N3/TST、TST、REM/TST指标值均较治疗前上升,SOL、NWAK、N1/TST、N2/TST指标值均较治疗前下降,其中TST、SOL、NWAK指标值与治疗前比较,差异有统计学意义(P<0.05);治疗后,观察组N3/TST、TST、REM/TST水平均高于对照组,SOL、NWAK、N1/TST、N2/TST水平均低于对照组,差异均有统计学意义(P<0.05)。2组GABA、GA水平均较治疗前升高,观察组GABA、GA水平均高于对照组,差异均有统计学意义(P<0.05)。结论:安神平衡针刺法联合艾司唑仑片治疗慢性失眠症患者效果确切,能够改善患者过度觉醒状态,减少觉醒次数,改善失眠状态,调整睡眠结构,改善睡眠质量。Objective:To observe the curative effect of Anshen Pingheng acupuncture method combined with estazolam tablets for chronic insomnia and its effect on serum neurotransmitter levels and hyperarousal state. Methods: A total of112 cases of patients with chronic insomnia were selected as the research objects,and were divided into the control group and the observation group according to the random number table method,with 56 cases in each group;three cases shed in the control group and two in the observation group. The control group was given the oral administration of eszolam tablets,and the observation group was additionally treated with Anshen Pingheng acupuncture method based on the treatment of the control group. Both groups were treated for three weeks. Before and after treatment,the changes in hyperarousal status including Hyperarousal Scale(HAS) and Pre-sleep Arousal Scale(PSAS), related neuroelectrophysiological effects including total sleep time(TST),sleep latency(SOL),number of awakenments(NWAK),1/2/3 stages of non-rapid eye movement(N1,N2, N3) and proportion of rapid eye movement sleep(REM) to TST as well as the levels of neurotransmitter includingγ-aminobutyric acid(GABA) contents and glutamic acid(GA) in serum in the two groups were compared. Results:The scores of HAS and PSAS in the two groups were decreased when compared with those before treatment,and the scores of HAS and PSAS in the observation group were lower than those in the control group,differences being significant(P<0.05). After treatment,the values of N3/TST,TST and REM/TST in the two groups were increased when compared with those before treatment,and the values of SOL,NWAK,N1/TST and N2/TST were decreased,among which the values of TST,SOL and NWAK showed a significant difference(P<0.05). After treatment,the levels of N3/TST,TST and REM/TST in the observation group were higher than those in the control group, and the levels of SOL, NWAK, N1/TST and N2/TST were lower,differences being significant(P<0.05). The levels of GABA and GA in the two

关 键 词：慢性失眠症 艾司唑仑 安神平衡针刺法 过度觉醒 神经递质 

分 类 号：R246.6[医药卫生—针灸推拿学]