中药灌洗负压技术联合生肌玉红膏外敷对湿热型糖尿病足疗效及炎症因子水平的影响  

Effect of Chinese Medicine Lavage and Negative Pressure Technique Combined with External Application of Shengji Yuhong Ointment on Curative Effect and Inflammatory Factors in Patients with Diabetic Foot of Damp-Heat Type

作　　者：沙丽君 马立人 马书平 SHA Lijun;MA Liren;MA Shuping

机构地区：[1]河南平顶山市中医医院,河南平顶山467000 [2]河南中医药大学,河南郑州450000

出　　处：《新中医》2022年第7期208-212,共5页New Chinese Medicine

摘　　要：目的:观察中药灌洗负压技术联合生肌玉红膏外敷对湿热型糖尿病足的疗效及相关炎性因子水平的影响。方法:选取120例湿热型糖尿病足患者进行研究,按随机数字表法分为对照组及研究组各60例,对照组采用基础治疗加生肌玉红膏,研究组在对照组治疗基础上联合中药灌洗负压技术治疗。2组均连续治疗1个月。比较2组治疗前后炎性因子[白细胞介素-13 (IL-13)、肿瘤坏死因子(TNF-α)、白细胞介素-6 (IL-6)]水平、创面面积、创面形态及症状的变化,比较2组治疗后创面愈合程度及临床疗效。结果:治疗后,2组IL-13、TNF-α、IL-6水平均较治疗前下降,研究组上述3项水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组创面面积均较治疗前减少(P<0.05),研究组创面面积小于对照组(P<0.05);研究组创面愈合程度高于对照组,差异有统计学意义(P<0.05)。治疗后,2组肉芽颜色和形态、气味、创周红肿、分泌物、疼痛评分均较治疗前下降,研究组上述5项评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组临床疗效总有效率为95.00%,对照组为81.67%,2组比较,差异有统计学意义(P<0.05)。结论:中药灌洗负压技术联合生肌玉红膏外敷治疗湿热型糖尿病足可抑制炎症反应,促进创面愈合,提高临床疗效。Objective:To observe the effect of the therapy of Chinese medicine lavage and negative pressure technique combined with the external application of Shengji Yuhong ointment on the level of inflammatory factors in patients with diabetic foot of damp-heat type. Methods:A total of 120 patients with diabetic foot of damp-heat type were selected and divided into the control group and the study group according to the random number table method,with 60 cases in each group. The control group was treated with basic treatment and Shengji Yuhong ointment, and the study group was additionally treated with Chinese medicine lavage and negative pressure technique based on the treatment of the control group. Both groups were treated for one month continuously. Before and after treatment, the changes of levels of inflammatory factors,including interleukin-13(IL-13),tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6),area of wound, morphology of wound and symptoms were compared between the two groups. After treatment, the degree of wound healing and clinical effects were compared between the two groups. Results:After treatment,the levels of IL-13,TNF-α and IL-6 in the two groups were decreased when compared with those before treatment,and the above three levels in the study group were lower than those in the control group,differences being significant(P<0.05). After treatment,the area of wound in both groups was decreased when compared with that before treatment(P<0.05),and the area of wound in the study group was smaller than that in the control group(P<0.05);the degree of wound healing in the study group was higher than that in the control group, the difference being significant(P<0.05). After treatment, the scores of color and morphology of granulation, smell, redness and swelling around the wound, secretion and pain in the two groups were decreased when compared with those before treatment and the above five scores in the study group were lower than those in the control group,differences being significant(P<0.05). After t

关 键 词：湿热型糖尿病足 中药灌洗负压技术 生肌玉红膏 创面愈合程度 炎症反应 

分 类 号：R587.2[医药卫生—内分泌]