Highly integrated watch for noninvasive continual glucose monitoring  

作　　者：Tianrui Chang Hu Li Nianrong Zhang Xinran Jiang Xinge Yu Qingde Yang Zhiyuan Jin Hua Meng Lingqian Chang 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology,Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China [2]Department of Biomedical Engineering,City University of Hong Kong,Hong Kong,China [3]General Surgery Department&Obesity and Metabolic Disease Center,China-Japan Friendship Hospital,Beijing 100029,China [4]Sense Future(HangZhou)Co.,Ltd,Hangzhou 311217,China

出　　处：《Microsystems & Nanoengineering》2022年第1期331-339,共9页微系统与纳米工程（英文）

基　　金：This work was supported by the Beijing Advanced Innovation Center for Biomedical Engineering,the National Natural Science Foundation of China(Grant No.32071407 and 62003023);the Beijing Natural Science Foundation(No.7212204);the Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20200109110201713).

摘　　要：This article reports a highly integrated watch for noninvasive continual blood glucose monitoring.The watch employs a Nafion-coated flexible electrochemical sensor patch fixed on the watchband to obtain interstitial fluid(ISF)transdermally at the wrist.This reverse iontophoresis-based extraction method eliminates the pain and inconvenience that traditional fingerstick blood tests pose in diabetic patients’lives,making continual blood glucose monitoring practical and easy.All electronic modules,including a rechargeable power source and other modules for signal processing and wireless transmission,are integrated onto a watch face-sized printed circuit board(PCB),enabling comfortable wearing of this continual glucose monitor.Real-time blood glucose levels are displayed on the LED screen of the watch and can also be checked with the smartphone user interface.With 23 volunteers,the watch demonstrated 84.34%clinical accuracy in the Clarke error grid analysis(zones A+B).In the near future,commercial products could be developed based on this lab-made prototype to provide the public with noninvasive continual glucose monitoring.

关 键 词：HIGHLY checked eliminate 

分 类 号：TH77[机械工程—仪器科学与技术]