大剂量静脉注射免疫球蛋白在重症皮肤病治疗中的应用进展  

Application of high-dose intravenous immunoglobulin therapy in severe dermatoses

作　　者：李丹琪 楼雨晨 陶娟[1] Li Danqi;Lou Yuchen;Tao Juan(Department of Dermatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Center of Skin Recovery and Theranostics,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科皮肤修复与诊疗技术湖北省工程研究中心,武汉430022

出　　处：《中华皮肤科杂志》2022年第5期455-459,共5页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81974245)。

摘　　要：大剂量静脉注射免疫球蛋白(IVIG)在部分难治性和危重皮肤病的治疗中疗效肯定,不良反应少。IgG的Fab段和Fc段可以通过结合各种自身抗原、自身抗体、补体等来介导特定的下游效应,以达到抗炎效果。该文综述IVIG的治疗机制,其在重症药疹、难治性皮肌炎和自身免疫性大疱病等重症皮肤病中的应用,以及特殊人群使用和不良反应等。High-dose intravenous immunoglobulin(IVIG)has emerged as an effective treatment option for some refractory and severe dermatoses with few adverse reactions.The Fab and Fc fragments of IgG can exert anti-inflammatory effect by mediating specific downstream reactions via binding to a variety of autoantigens,autoantibodies and complements.This review summarizes action mechanisms of IVIG,focuses on the progress towards its application in severe dermatoses(such as severe drug eruption,refractory dermatomyositis and autoimmune bullous diseases)and special populations,as well as its adverse reactions.

关 键 词：免疫球蛋白类 静脉内 皮肤疾病 重症皮肤病 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]