氨甲环酸治疗黄褐斑的研究进展  

Tranexamic acid for the treatment of melasma

作　　者：胡烨蓓 宋秀祖[2] Hu Yebei;Song Xiuzu(Department of Dermatology,The Third People′s Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University,Hangzhou 310009,China;Department of Dermatology,The Third People′s Hospital of Hangzhou,Hangzhou 310009,China)

机构地区：[1]浙江中医药大学附属杭州第三医院皮肤科,杭州310009 [2]杭州市第三人民医院皮肤科,杭州310009

出　　处：《中华皮肤科杂志》2022年第5期460-462,共3页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81872517);浙江省基础公益研究计划项目(LGF18H110001);杭州市医学重点专科专病项目(20130733Q24)。

摘　　要：氨甲环酸可以通过多个环节治疗黄褐斑,包括抑制真皮血管形成,减少肥大细胞数目并抑制其活性,减少基底膜带损伤,抑制表皮黑素合成和转运,促进皮肤屏障功能恢复等。本文综述氨甲环酸治疗黄褐斑的机制及疗效,为临床应用提供更多依据。Tranexamic acid can treat melasma through multiple steps,such as inhibiting dermal angiogenesis,reducing the number of mast cells and inhibiting their activity,reducing damage to the basement membrane zone,inhibiting melanin synthesis and transport in the epidermis,and promoting the recovery of skin barrier function.This review summarizes the mechanism and efficacy of tranexamic acid in the treatment of melasma,providing more evidence for its clinical application.

关 键 词：黄褐斑 药物疗法 氨甲环酸 治疗结果 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]