IL-31及其受体在免疫相关性疾病中的作用  

The role of IL-31 and its receptor in immune-related diseases

作　　者：荣春丽 闫昌鑫 周海舟[1] Rong Chunli;Yan Changxin;Zhou Haizhou(Department of Laboratory,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院检验科,哈尔滨150001

出　　处：《国际免疫学杂志》2022年第1期58-62,共5页International Journal of Immunology

基　　金：国家自然科学基金(81772261)。

摘　　要：白细胞介素(interleukin,IL)-31是2004年新发现的一种细胞因子,其受体是由IL-31受体A(IL-31 receptor alpha,IL-31RA)和抑瘤素M受体(oncostatin-M receptor beta,OSMR)组成的异源性二聚体。最近的研究表明,IL-31通过刺激促炎性细胞因子分泌,可以调节细胞增殖,并参与组织重塑。此外,IL-31在支持辅助性T细胞(helper T cells,Th)2免疫方面也具有潜在的免疫调节作用,提示IL-31受体阻断治疗方法可用于治疗Th2型相关疾病。文章主要对IL-31及其受体在免疫相关性疾病中的作用作一综述。Interleukin(IL)-31 is a newly discovered cytokine in 2004.Its receptor is a heterogenic dimer composed of IL-31 receptor alpha A(IL-31RA)and oncostatin M receptor beta(OSMR).Recent studies have shown that,IL-31 regulates cell proliferation and participates in tissue remodeling by stimulating pro-inflammatory cytokines.In addition,IL-31 also have potential immunomodulatory effects in supporting helper T cells(Th)2 immunity,indicating that IL-31 receptor blocker therapies can be used to treat Th2-related diseases.This paper mainly reviews the role of IL-31 and its receptor in immune-related diseases.

关 键 词：白细胞介素-31 白细胞介素-31受体 免疫相关性疾病 

分 类 号：R593[医药卫生—内科学]