Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing- antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding  

作　　者：Sheng Lin Zimin Chen Xindan Zhang Ao Wen Xin Yuan Chongzhang Yu Jing Yang Bin He Yu Cao Guangwen Lu 

机构地区：[1]West China Hospital Emergency Department(WCHED),State Key Laboratory of Biotherapy,West Chino Hospital,Sichuan University,610041 Chengdu,Sichuan,China [2]Disaster Medicine Center,West China Hospital,Sichuan University,610041 Chengdu,Sichuan,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第3期622-624,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(Grant no.2021YFC2301400);the National Natural Science Foundation of China(Grant no.82041042);the special research fund on COVID-19 of West China Hospital,Sichuan University(Grant no.HX-2019-nCoV-004);the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(Grant no.ZYYC20008).

摘　　要：Dear Editor,The recent-emerging Omicron variant(B.1.1.529 lineage)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has raised serious public concern because of its rapid regional-and global-transmission.As of 11th January 2022,the Omicron variant has spread to 140 countries,territories or areas through infected air travelers,and the number is continuously increasing.

关 键 词：ACE2 DECOY RBD 

分 类 号：R563.1[医药卫生—呼吸系统]