细胞焦亡在糖尿病大血管并发症中作用的研究进展  

The role of pyroptosis in the macrovascular complications of diabetes

作　　者：马延洁 徐明 MA Yan-jie;XU Ming(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211100,China)

机构地区：[1]中国药科大学基础医学与临床药学学院,江苏南京211100

出　　处：《药学学报》2022年第4期884-891,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81973509)。

摘　　要：细胞焦亡是一种炎症性细胞程序死亡模式。体内外研究表明,细胞焦亡主要通过激活炎性小体、活化天冬氨酸特异蛋白酶-1/4/5/11 (caspase-1/4/5/11)、切割gasdermin家族成员D (gasdermin D, GSDMD)、释放白细胞介素-18 (interleukin-18, IL-18)和IL-1β等炎性细胞因子参与糖尿病大血管并发症的发生发展。近几年,细胞焦亡通过炎症的级联反应导致的全身慢性炎症对糖尿病大血管并发症的影响受到人们的持续关注。本文对细胞焦亡在糖尿病大血管并发症中的研究和相关药物进行阐述,为临床治疗糖尿病大血管并发症提供新思路。Pyroptosis is a form of inflammatory programmed cell death pathway. In vitro and in vivo studies have shown that pyroptosis contributes to the development of macrovascular complications of diabetes, mainly through activating inflammasomes and caspase-1/4/5/11, cleaving gasdermin D(GSDMD), releasing interleukin-18(IL-18), IL-1β and other inflammatory cytokines. In recent years, the effect of systemic chronic inflammation caused by pyroptosis through inflammatory cascade reaction on macrovascular complications of diabetes has received long-term attention. This article reviews studies of pyroptosis in macrovascular complications of diabetes and the related drugs to provide promising thought for treating macrovascular complications of diabetes in clinical.

关 键 词：细胞焦亡 炎性小体 糖尿病 大血管并发症 慢性炎症 

分 类 号：R966[医药卫生—药理学]