肠道药物转运体在炎症性肠病状态下的变化及机制研究进展  

Research progress on the changes and mechanism of intestinal drug transporters in inflammatory bowel disease

作　　者：董敏磊 罗筠 蒋惠娣[1] 李萍 DONG Min-lei;LUO Jun;JIANG Hui-di;LI Ping(College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Hangzhou First People's Hospital,Hangzhou 310006,China)

机构地区：[1]浙江大学药学院,浙江杭州310058 [2]杭州市第一人民医院,浙江杭州310006

出　　处：《药学学报》2022年第4期943-951,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金面上项目(81773804)。

摘　　要：炎症性肠病(inflammatory bowel disease, IBD)是一种以肠道慢性和进行性炎症为特征的疾病,由于其难以根治、易复发,严重影响了患者的生存质量。肠道作为物质吸收的主要器官,肠道中药物转运体的改变会导致内外源性物质在体内的行为发生改变,在IBD患者的肠道炎症组织中也已经观察到多种药物转运体表达和功能的改变。本文综述了肠道药物转运体在IBD状态下的变化及其相关机制研究进展,为寻找治疗IBD的新策略和临床合理用药提供理论基础。Inflammatory bowel disease(IBD) is a disease characterized by chronic and progressive inflammation of the intestinal tract, which seriously affects the quality of life of patients because it is difficult to cure and easy to recur. As the main organ of substance absorption, the changes of intestinal drug transporters will lead to changes in the behavior of endogenous and exogenous substances in vivo. Changes in the expression and function of a variety of drug transporters have also been observed in intestinal inflammatory tissues of patients with IBD.This paper reviews the changes of intestinal drug transporters in IBD and its related mechanisms, which provides a theoretical basis for finding new strategies for the treatment of IBD and clinical rational drug use.

关 键 词：炎症性肠病 肠道药物转运体 调控 机制 

分 类 号：R917[医药卫生—药物分析学]