致导管相关性血流感染的长孢洛德酵母菌及生物学特性分析  

Lodderomyces elongisporus causing catheter-related bloodstream infection and its biological characteristics

作　　者：耿朝萌 贾宗海 马琪 刘泽世[3] 雷静 方乐 雷珂 Geng Zhaomeng;Jia Zonghai;Ma Qi;Liu Zeshi;Lei Jing;Fang Le;Lei Ke(Clinical Laboratory Department of 521 hospital of Norinco Group,Xi'an 710065,China;Intensive Care Unit of Second Affilicated Hospital of Xi,an Jiaotong University,Xi'an 710004,China;Clinical Laboratory Department of Second Affilicated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]兵器工业521医院检验科,西安710065 [2]西安交通大学第二附属医院重症医学中心,西安710004 [3]西安交通大学第二附属医院检验科,西安710004

出　　处：《中华检验医学杂志》2022年第4期399-402,共4页Chinese Journal of Laboratory Medicine

摘　　要：分析临床1例脑梗死患者体温达38.4℃时外周静脉血及导管血检出的长孢洛德酵母菌的生物学特性,观察科玛嘉念珠菌显色平板的菌落形态和醋酸钠培养基上子囊孢子的产生情况,利用Vitek 2 compact、基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF MS)、测序分析分别进行鉴定,并进行药敏试验研究,以提高实验室对该菌的鉴定水平。药敏试验结果显示此例分离株对多种抗真菌药物的MIC值较低。临床给予拔除中心静脉置管,并使用抗真菌药物治疗至最后一次血培养阳性后2周,用药期间多次复查血培养均为阴性,患者无发热,各项感染指标基本降至正常,可供临床参考。In order to improve the laboratory identification ability of Lodderomyces elongisporus,we analyzed the main biological characteristics of Lodderomyces elongisporus isolated from peripheral venous blood and catheter blood of a brain stem infarction patient with a body temperature of 38.4℃,observed the colony color of the strain on CHROMagar Candida medium and the ascospores on Mcclary agar,identified the isolates with Vitek 2 compact,MALDI-TOF MS and sequence analysis,and tested the MICs with borth microdilution.The MICs of antifungal agents against Lodderomyces elongisporus are well below the normal values of these drugs.The central venous catheter was removed and antifungal drugs were used until two weeks after the last positive blood culture.During the medication perios,the blood culture was repeatedly negative,the patient had no fever and the infection index decreased to normal,which can be used for clinical reference.

关 键 词：感染 长孢洛德酵母菌 临床实验室技术 

分 类 号：R446.5[医药卫生—诊断学]