Biosynthesis of titanium dioxide nanoparticles using Hypericum perforatum and Origanum vulgare extracts and their main components,hypericin and carvacrol as promising antibacterial agents  

作　　者：Mojtaba Khaksarian Mahmoud Bahmani Morovat Taherikalani Behnam Ashrafi Mahmoud Rafieian-Kopaei Naser Abbasi 

机构地区：[1]Department of Physiology and Pharmacology,School of Medicine,Razi Herbal Medicines Research Center,Lorestan University of Medical Sciences,Khorramabad,Iran [2]Biotechnology and Medicinal Plants Research Center,Ilam University of Medical Sciences,Ilam,Iran [3]Razi Herbal Medicines Research Center,Lorestan University of Medical Sciences,Khorramabad,Iran [4]Department of Microbiology,School of Medicine,Lorestan University of Medical Sciences,Khorramabad,Iran [5]Medical Plants Research Center,Basic Health Sciences Institute,Shahrekord University of Medical Sciences,Shahrekord,Iran [6]department of Pharmacology,Faculty of Medicine [7]Ilam University of Medical Sciences,Ilam,Iran

出　　处：《Journal of Traditional Chinese Medicine》2022年第2期167-175,共9页中医杂志（英文版）

基　　金：financial support of the Research and Technology Deputy of Lorestan University of Medical Sciences,Khorramabad,Iran。

摘　　要：OBJECTIVE:To evaluate the anti-bacterial activities of titanium dioxide(Ti O;)nanoparticles of Origanum(O.)vulgare and Hypericum(H.)perforatum extracts,carvacrol and hypericin against Staphylococcus(S.)aureus.METHODS:In this study,Ti O;nanoparticles of O.vulgare and H.perforatum extracts,carvacrol and hypericin,were prepared and their antibacterial effects were evaluated against Staphylococcus(S.)aureus.In this study,scanning electron microscope,fourier transform infrared spectrometer,atomic force microscopy,dynamic light scattering and zeta potential were used to investigate the structure of synthesized drugs.RESULTS:Anti-bacterial activity of synthesized NPs was tested by minimum inhibitory concentration(MIC),minimum bactericidal concentration and disc diffusion method.MICs of Ti O;-NPs synthesized using O.vulgare,H.perforatum,carvacrol and hypericin and Ti O;were obtained 250,62.5,250,and 250,and 500μg/m L,respectively.The MBCs for all of these were obtained 1000μg/m L.CONCLUSION:Green-synthesized of Ti O;nanoparticles provides a promising approach to the use of O.vulgare and H.perforatum,carvacrol and hypericin as novel agents and safer antibacterial compounds,especially anti-S.aureus compounds.

关 键 词：plant MEDICINAL MEDICINE TRADITIONAL anti-infective agents active ingredient nano-compounds 

分 类 号：R284[医药卫生—中药学]