DbcAMP-Ca联合美托洛尔治疗心衰伴心律失常  

DbcAMP-Ca combined with metoprolol sustained-release tablets for the treatment of CHF with arrhythmia

作　　者：杨启岭 段卡丹 邱梅红 张鲜鲜 Yang qiling;Duan kadan;Qiu meihong;Zhang xianxian(Department of Cardiology,Luoyang Central Hospital,Zhengzhou University,Zhenzhou,471000,China.)

机构地区：[1]郑州大学附属洛阳中心医院心内科,471000

出　　处：《临床心电学杂志》2022年第1期33-36,41,共5页Journal of Clinical Electrocardiology

摘　　要：目的探讨二丁酰环磷腺苷钙(dbcAMP-Ca)与美托洛尔缓释片联合用于慢性心力衰竭(CHF)伴心律失常治疗对症状缓解及心功能改善的效果。方法以2019年6月至2020年6月本院接收的82例CHF伴心律失常患者为对象,根据随机数字表法将其分为两组,对照组41例予以dbcAMP-Ca治疗,观察组41例予以dbcAMP-Ca联合美托洛尔缓释片治疗,对比两组心肌细胞损伤指标、症状缓解情况及心功能。结果观察组治疗后氨基末端脑钠肽前体(NT-proBNP)、心肌肌钙蛋白Ⅰ(cTnI)比对照组低(p<0.05);观察组用药后1个月、3个月、6个月时窦性心律维持率均比对照组高(p<0.05);观察组治疗后左心室舒张末期容积(LVEDV)比对照组低,左室射血分数(LVEF)及心输出量(CO)比对照组高(p<0.05),且观察组心功能分级优于对照组(p<0.05)。结论DbcAMP-Ca与美托洛尔缓释片联合用于CHF伴心律失常治疗可有效减轻心肌损伤,维持窦性心律,并且进一步改善患者心功能。Objective To explore the effect of combination of dibutyryl cyclic adenosine calcium(dbcAMP-Ca)and metoprolol sustained-release tablets in the treatment of chronic heart failure(CHF)with arrhythmia on symptom relief and improvement of cardiac function.Methods Eighty-two cases of patients with CHF and arrhythmia who were admitted to our hospital from June 2019 to June 2020 were collected,randomly divided into two groups according to the random number table method.Forty-one cases of patients in the control group were treated with dbcAMP-Ca,and 41 cases of patients in the observation group were treated with dbcAMP-Ca combined with metoprolol sustained-release tablets.The indicators of cardiomyocyte damage,symptom relief and cardiac function were compared between the two groups.Results In the observation group,the N-terminal pro-brain natriuretic peptide(NT-proBNP)and cardiac troponin I(cTnI)after treatment were lower than the control group(p<0.05).In the observation group,the maintenance rate of sinus rhythm at 1 month,3 months,and 6 months after treatment were higher than the control group(p<0.05).In the observation group,the left ventricular end diastolic volume(LVEDV)after treatment was lower than the control group,the left ventricular ejection fraction(LVEF)and cardiac output(CO)were higher than the control group(p<0.05),and in the observation group,the classification of cardiac function was better than the control group(p<0.05).Conclusions The combination of dbcAMP-Ca and metoprolol sustained-release tablets in the treatment of CHF with arrhythmia can effectively reduce myocardial damage,maintain sinus rhythm,as well as further improve the heart function of patients.

关 键 词：二丁酰环磷腺苷钙 美托洛尔缓释片 慢性心力衰竭 心律失常 心功能 

分 类 号：R541.7[医药卫生—心血管疾病] R540.41[医药卫生—内科学]