CaM、OX40^(+)Treg、Cys C与急性脑梗死早期机械再通术后血流再灌注程度的相关性  

Correlation between CaM,OX40^(+)Treg,Cys C and the degree of blood reperfusion after mechanical recanalization in the early stage of acute cerebral infarction

作　　者：王佳[1] WANG Jia(Huabei Petroleum Administration Bureau General Hospital,Cangzhou Hebei 062550,China)

机构地区：[1]华北石油管理局总医院,河北沧州062550

出　　处：《中国急救复苏与灾害医学杂志》2022年第4期465-468,473,共5页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：中国石油华北油田科技项目(编号:2019-HB-G0101)。

摘　　要：目的探讨钙调蛋白(CaM)、调节性T细胞上共刺激分子OX40(OX40^(+)Treg)、胱抑素C(Cys C)与急性脑梗死(ACI)早期机械再通术后血流再灌注程度的相关性。方法选取华北油田管理局总医院126例行早期机械再通术的ACI患者,根据梗死血管是否再通分为非再通组(n=22)和再通组(n=104),比较两组CaM、OX40^(+)Treg、Cys C水平,分析血管再通的相关影响因素,并比较不同CaM、OX40^(+)Treg、Cys C水平者术后改良缺血再灌注分级(mTICI),分析CaM、OX40^(+)Treg、Cys C与mTICI分级的相关性及预测血管再通的价值。结果非再通组CaM、OX40^(+)Treg、Cys C血清水平高于再通组(P<0.05);CaM、OX40^(+)Treg、Cys C高水平者,其术后mTICI分级高于低水平者(P<0.05);CaM、OX40^(+)Treg、Cys C与术后mTICI分级间存在负相关关系;CaM、OX40^(+)Treg、Cys C均为ACI患者早期机械再通术血管再通的影响因素(P<0.05);CaM、OX40^(+)Treg、Cys C预测血管再通的曲线下面积(AUC)分别为0.646、0.770、0.844,联合预测的AUC最大为0.925。结论CaM、OX40^(+)Treg、Cys C与ACI患者早期机械再通术血管再通情况显著相关,早期检测各指标可辅助临床预测血管再通情况。Objective To investigate the relationship between calmodulin(CaM),costimulatory molecules OX40(OX40^(+)Treg)on regulatory T cells,cystatin C(Cys C)and acute cerebral infarction(ACI)after early mechanical recanalization.Correlation of the degree of perfusion.Methods 126 ACI patients who underwent early mechanical recanalization in our hospital were selected and divided into non-recanalization group(n=22)and recanalization group(n=104)according to whether the infarcted vessel was recanalized.The two groups were compared with CaM and OX40^(+)Treg and Cys C levels,analyze the related influencing factors of vascular recanalization,and compare the postoperative modified ischemia-reperfusion classification(mTICI)in patients with different CaM,OX40^(+)Treg,and Cys C levels,analyze CaM,OX40^(+)Treg,Cys C Correlation with mTICI classification and the value of predicting vascular recanalization.Results CaM,OX40^(+)Treg,and Cys C in the non-recanalization group were higher than those in the recanalization group(P<0.05);those with high levels of CaM,OX40^(+)Treg and Cys C were higher than those with low levels of mTICI after surgery(P<0.05);CaM,OX40^(+)Treg,Cys C and postoperative mTICI grade are negatively correlated(P<0.05);CaM,OX40^(+)Treg,Cys C are all influencing factors of early mechanical recanalization in patients with ACI(P<0.05);CaM,OX40^(+)Treg,Cys C predict the area under the curve(AUC)of vascular recanalization are 0.646,0.770,0.844,respectively,and the combined predicted AUC is the largest,which is 0.925.Conclusion CaM,OX40^(+)Treg,Cys C are significantly related to the recanalization of early mechanical recanalization in patients with ACI.Early detection of various indicators can help clinical prediction of recanalization.

关 键 词：急性脑梗死 机械再通术 钙调蛋白 调节性T细胞上共刺激分子OX40 胱抑素C 

分 类 号：R651.1[医药卫生—外科学]