不同抗生素药物对儿童支原体肺炎疗效及对免疫功能的影响  

The Effect of Different Antibiotics on Mycoplasma Pneumonia in Children and its Influence on Immune Function

作　　者：王毛毛 WANG Mao-mao(Department of Pediatrics,Maternal and Child Health Hospital of Xinmi City,Zhengzhou,Henan,452370,China)

机构地区：[1]新密市妇幼保健院儿一科,河南郑州452370

出　　处：《黑龙江医学》2022年第7期823-826,共4页Heilongjiang Medical Journal

摘　　要：目的:探讨不同抗生素药物对儿童支原体肺炎(MPP)疗效及对免疫功能的影响。方法:选择2018年3月—2019年3月新密市妇幼保健院收治的90例MPP患儿,单号为Dy组(阿奇霉素),双号为Ly组(阿莫西林-克拉维酸钾+阿奇霉素),每组各45例,比较两组患者临床疗效,免疫球蛋白变化,临床症状恢复时间,肺功能,不良反应情况。结果:Dy组治愈21例,较Ly组少8例,Ly组好转14例,较Dy组多1例,Dy组无效11例,Ly组无效4例,Dy组总有效率为77.78%,明显低于Ly组的95.56%,差异有统计学意义(χ^(2)=3.916,P<0.05)。用药前两组IgA、IgG、IgM值比较,差异无统计学意义(t=0.153、0.095、0.268,P>0.05),用药后IgA、IgG、IgM值水平均低于用药前,差异有统计学意义(t=3.709、2.582、3.901,P<0.05),且Dy组IgA、IgG、IgM水平均低于Ly组。Dy组临床症状恢复时间均较Ly组有所延长。两组患者用药后各参数指标值较用药前有显著升高,且与Dy组肺功能相关参数比较,Sy组各值均有显著升高。Dy组不良反应发生率,较Ly组高。结论:阿莫西林—克拉维酸钾联合阿奇霉素对MPP患者有明显治疗效果,患儿免疫功能及肺功能提升明显。Objective:To investigate the effect of different antibiotics on Mycoplasma pneumoniae(MPP)and immune function in children.Methods:90 children with MPP were selected,the single number was Dy group(azithromycin),the double number was Ly group(amoxicillin clavulanate potassium+azithromycin),with 45 cases in each group.The clinical efficacy of Dy group and Ly group was compared,the immunoglobulin changes,clinical symptoms recovery time and lung function of the Dy group and Ly group were observed,and adverse reactions in the Dy group and Ly group were recorded.Results:21 cases were cured in the Dy group,8 cases less than in the Ly group.14 cases in the Ly group improved,1 case more than in the Dy group.There were 11invalid cases in the Dy group and 4 invalid cases in the Ly group.The total effective rate in the Dy group was 77.78%,which was significantly lower than the 95.56% in the Ly group,and the difference between the groups was statistically significant(χ^(2)=3.916,P<0.05).There was no significant difference in IgA,IgG and IgM values between the Dy group and the Ly group before treatment(t=0.153,0.095,0.268,P>0.05).The levels of IgA,IgG and IgM after medication were lower than before medication,the difference was statistically significant(t=3.709,2.582,3.901,P<0.05).And the levels of IgA,IgG and IgM in the Dy group were lower than those in the Ly group.The recovery time of clinical symptoms in the Dy group was longer than that in the Ly group.The index values of the parameters of the two groups of patients were significantly higher than those before the treatment,and compared with the relevant parameters of lung function in the Dy group,the values of the Ly group were significantly increased.The incidence of adverse reactions in the Dy group was 28.89%,which was higher than 20.00% in the Ly group.Conclusion:Amoxicillinclavulanate potassium combined with azithromycin has a significant therapeutic effect on patients with MPP,and the immune function and lung function of the children are significantly improved.

关 键 词：支原体肺炎 免疫功能 阿奇霉素 阿莫西林-克拉维酸钾 

分 类 号：R563[医药卫生—呼吸系统]