肾动脉栓塞术联合肾上腺色腙片对急性肾出血患者凝血功能、肾功能的影响  

Effects of Renal Artery Embolization Combined with Adrenal Hydrazone Tablets on Coagulation Function and Renal Function in Patients with Acute Renal Hemorrhage

作　　者：李文峰[1] 顾豫飞[1] 张辉 LI Wenfeng;GU Yufei;ZHANG Hui(Dept.of Urology,the Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Dept.of Orthopedics,Shanghai Fengxian District Central Hospital,Shanghai 201499,China)

机构地区：[1]上海交通大学医学院附属第九人民医院泌尿外科,上海200011 [2]上海市奉贤区中心医院骨科,上海201499

出　　处：《中国医院用药评价与分析》2022年第4期416-419,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：上海市卫生系统优秀青年医学人才培养计划项目(No.PWRq2018-17)。

摘　　要：目的:探讨肾动脉栓塞术联合肾上腺色腙片对急性肾出血患者凝血功能、肾功能的影响。方法:选取2019年9月至2021年9月于上海交通大学医学院附属第九人民医院就诊的急性肾出血患者61例,采用随机数字表法分为单一治疗组30例、联合治疗组31例。单一治疗组患者使用肾动脉栓塞术治疗,联合治疗组患者使用肾动脉栓塞术联合肾上腺色腙片治疗。对比两组患者的肾功能,采用免疫透射比浊法检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(FIB)水平,酶联免疫吸附法检测肿瘤坏死因子α(TNF-α)、白细胞介素(IL)1和IL-22水平;观察两组患者的治疗效果和并发症发生情况。结果:治疗后,联合治疗组患者血细胞比容、血红蛋白水平高于单一治疗组,心率低于单一治疗组,差异均有统计学意义(P<0.05)。治疗后,联合治疗组患者血肌酐、24 h尿蛋白和尿素氮水平低于单一治疗组,差异均有统计学意义(P<0.05)。治疗后,联合治疗组患者PT、APTT长于单一治疗组,FIB、TNF-α、IL-1和IL-22水平低于单一治疗组,差异均有统计学意义(P<0.05)。联合治疗组患者的总有效率为96.77%(30/31),高于单一治疗组的76.67%(23/30);联合治疗组患者的并发症发生率为3.23%(1/31),低于单一治疗组的20.00%(6/30),上述差异有统计学意义(P<0.05)。结论:肾动脉栓塞术联合肾上腺色腙片治疗急性肾出血,患者的肾功能提高,凝血功能得到改善,炎症反应得到有效调节,治疗效果显著。OBJECTIVE:To probe into the effects of renal artery embolization combined with Adrenal hydrazone tablets on coagulation function and renal function in patients with acute renal hemorrhage.METHODS:A total of 61 patients with acute renal hemorrhage admitted into the Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine from Sept.2019 to Sept.2021 were selected and divided into the single treatment group(n=30)and the combined treatment group(n=31)via random number table.The single treatment group was treated with renal artery embolization,while the combined treatment group received renal artery embolization combined with Adrenal hydrazone tablets.The renal function of two groups was compared.Plasma prothrombin time(PT),activated partial thrombin time(APTT)and fibrinogen(FIB)levels were determined by immunoturbidimetry,and tumor necrosis factor α(TNF-α),interleukin(IL)-1 and IL-22 levels were determined by enzyme-linked immunosorbent assay.The treatment effects and incidence of complications were observed.RESULTS:After treatment,the levels of hematocrit and hemoglobin in the combined treatment group were higher than those in the single treatment group,and the heart rate was lower than that in the single treatment group,with statistically significant differences(P<0.05).After treatment,the levels of serum creatinine,24 h urine protein and blood urea nitrogen in the combined treatment group were lower than those in the single treatment group,the differences were statistically significant(P<0.05).After treatment,PT and APTT in the combined treatment group were longer than those in the single treatment group,and the levels of FIB,TNF-α,IL-1 and IL-22 were lower than those in the single treatment group,the differences were statistically significant(P<0.05).The total effective rate in the combined treatment group was 96.77%(30/31),higher than 76.67%(23/30)in the single treatment group;the incidence of complications in the combined treatment group was 3.23%(1/31),lower than 20.00%(6/30)i

关 键 词：急性肾出血 肾动脉栓塞术 肾上腺色腙片 肾功能 凝血功能 

分 类 号：R973[医药卫生—药品]