荧光素钠注射液引导手术切除脑胶质瘤临床疗效的系统评价  

Systematic Review on Clinical Efficacy of Fluorescein Sodium Injection-Guided Surgical Resection of Glioma

作　　者：何娟娟 李显培 黄天敏 张宏亮[3] HE Juanjuan;LI Xianpei;HUANG Tianmin;ZHANG Hongliang(Dept.of Pharmacy,Chongzuo the Second People’s Hospital,Guangxi Chongzuo 532200,China;Dept.of Pharmacy,Chongzuo Hospital of Traditional Chinese Medicine and Zhuang Medicine,Guangxi Chongzuo 532200,China;Dept.of Pharmacy,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]崇左市第二人民医院药剂科,广西崇左532200 [2]崇左市中医壮医医院药剂科,广西崇左532200 [3]广西医科大学第一附属医院药学部,南宁530021

出　　处：《中国医院用药评价与分析》2022年第4期475-478,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：广西自然科学基金项目(No.2017GXNSFBA198177);广西中医药适宜技术开发与推广项目(No.GZSY20-10)。

摘　　要：目的:系统评价荧光素钠注射液引导手术切除脑胶质瘤的临床疗效。方法:通过检索PubMed、Embase、中国知网、维普数据库、中国生物医学文献数据库及万方数据库,收集荧光素钠注射液引导手术切除脑胶质瘤的随机对照试验(RCT),检索时限均为建库至2021年4月,对符合质量标准的RCT进行Meta分析,采用RevMan 5.2软件进行统计学分析。结果:共纳入6篇RCT研究,涉及333例患者;观察组患者在常规脑胶质瘤显微手术切除过程中,通过静脉注射荧光素钠注射液将肿瘤组织染色,根据其荧光染色强弱判断肿瘤的边界进行肿瘤切除;对照组患者采用常规显微手术切除脑胶质瘤。Meta分析结果显示,观察组患者肿瘤全切除率明显高于对照组(OR=5.51,95%CI=3.28~9.24,P<0.00001),术后脑胶质瘤复发率明显低于对照组(OR=0.30,95%CI=0.15~0.60,P=0.0006),差异均有统计学意义;两组患者平均手术持续时间、平均住院时间的差异均无统计学意义(P>0.05)。结论:与常规显微手术相比,采用荧光素钠注射液引导手术切除脑胶质瘤的肿瘤全切除率更高,术后肿瘤复发率更低。OBJECTIVE:To systematically evaluate the clinical efficacy of using fluorescein sodium injection to guide surgical resection of glioma.METHODS:PubMed,Embase,CNKI,VIP,CBM and Wanfang Data were retrieved to collect the randomized controlled trials(RCT)of efficacy of fluorescein sodium injection-guided surgical resection of glioma.The retrieval time was from the establishment of the database to Apr.2021.Meta-analysis was performed on RCT that met the quality standards,and RevMan 5.2 was used for statistical analysis.RESULTS:A total of 6 RCT with 333 patients were included.During the routine microsurgical resection of glioma in the observation group,the tumor tissue was stained by intravenous injection of sodium fluorescein injection,and the tumor boundary was judged according to the intensity of the fluorescent staining to perform tumor resection;the control group was resected by conventional microsurgery glioma.Meta-analysis showed that the total resection rate of glioma in the observation group was significantly higher than that in the control group(OR=5.51,95%CI=3.28-9.24,P<0.00001),the recurrence rate of glioma in the observation group after surgery was significantly lower than that in the control group(OR=0.30,95%CI=0.15-0.60,P=0.0006),with statistically significant differences.There were no significant differences in the average duration of surgery and average length of stay between two groups(P>0.05).CONCLUSIONS:Compared with conventional microsurgery,fluorescein sodium injection-guided surgical resection of glioma has a higher total tumor resection rate and a lower postoperative tumor recurrence rate.

关 键 词：荧光素钠注射液 脑胶质瘤 肿瘤全切除率 META分析 

分 类 号：R981[医药卫生—药品]