噻托溴铵在COPD合并肺气肿患者中的应用及对肺功能的影响  

Application of tiotropium bromide in COPD patients with emphysema and its effect on pulmonary function

作　　者：吴小红 Wu Xiaohong(Department of Internal Medicine,People's Hospital of Xuwen County,Guangdong Province,Xuwen 524199,China)

机构地区：[1]广东省徐闻县人民医院内科,524199

出　　处：《现代养生》2022年第12期991-993,共3页Health Protection and Promotion

摘　　要：目的观察慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺气肿患者中应用噻托溴铵的治疗效果。方法选择2020年3月-2021年10月医院诊治的98例COPD合并肺气肿患者作为研究对象,根据组间性别、年龄、病程等基本资料均衡可比的原则分为对照组和观察组,每组49例。对照组采用生理盐水、普米克令舒、万托林进行治疗,观察组采用生理盐水、普米克令舒、万托林与噻托溴铵进行治疗。对比分析两组治疗疗效、肺功能状况、住院一般情况与并发症。肺功能情况包括第一秒用力呼气容积(forced expiratory volume in the first second,FEV1)与第一秒用力呼气量占用力肺活量(forced vital capacity,FVC)比例,即FEV1/FVC值。结果治疗后,观察组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组FEV1与FEV1/FVC值均有改善,但观察组肺功能好转优于对照组,差异有统计学意义(P<0.05);对照组患者住院时间明显延长,并且对照组患者住院总费用高于观察组,两组差异有统计学意义(P<0.05);对照组并发症发生率高于观察组,但差异无统计学意义(P>0.05)。结论在普米克令舒、万托林治疗基础上,对COPD合并肺气肿患者应用噻托溴铵能够促进患者肺功能好转,缩短住院时间,并可在一定程度上减少治疗不良反应,具有一定临床价值。Objective To observe the therapeutic effect of tiotropium bromide in patients with chronic obstructive pulmonary disease(COPD)complicated with emphysema.Methods A total of 98 patients with COPD complicated with emphysema treated in the hospital from March 2020 to October 2021 were selected as the research object.According to the principle of balanced and comparable basic data such as gender,age and course of disease,they were divided into control group and observation group,with 49 cases in each group.The control group was treated with normal saline,Pulmicort Respules and Ventolin,while the observation group was treated with normal saline,Pulmicort Respules,Ventolin and tiotropium bromide.The therapeutic effects,pulmonary function,general hospitalization conditions and complications of the two groups were compared and analyzed.Pulmonary function included forced expiratory volume in the first second(FEV1)and the proportion of FEV1 in forced vital capacity(FVC),that was,FEV1/FVC value.Results After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).FEV1 and FEV1/FVC were improved in the two groups,but the improvement of pulmonary function in the observation group was better than that in the control group(P<0.05).The hospitalization time of patients in the control group was significantly longer,and the total hospitalization cost of patients in the control group was higher than that in the observation group,the difference between the two groups was statistically significant(P<0.05).The incidence of complications in the control group was higher than that in the observation group,but the difference was not statistically significant(P>0.05).Conclusion Based on the treatment of Pulmicort Respules and Ventolin,the application of tiotropium bromide in patients with COPD complicated with emphysema can promote the improvement of pulmonary function,shorten the length of hospital stay,and reduce adverse reactions to a certain extent,which has a certain clinical value.

关 键 词：噻托溴铵 普米克令舒 万托林 慢性阻塞性肺疾病 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]