沉默信息调节因子1相关信号通路与肾纤维化关系的研究进展  

Research Progress in Relationship between Silent Information Regulator 1 Related Signal Pathways and Renal Fibrosis

作　　者：黄欣[1] 程帆[1] HUANG Xin;CHENG Fan(Department of Urology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院泌尿外科,武汉430060

出　　处：《医学综述》2022年第8期1457-1462,共6页Medical Recapitulate

基　　金：国家自然科学基金(81870471,81800617)。

摘　　要：肾纤维化,尤其是肾小管肾间质纤维化,是各种慢性肾脏疾病发展至终末期肾病的病理基础,同时也是预测肾功能不全预后的可靠预测因子。肾脏氧化应激、细胞凋亡及炎症等导致的细胞功能障碍会进一步加重肾组织损伤,而这一过程与肾纤维化密切相关,主要表现为肾小球硬化、肾间质纤维化、细胞外基质堆积及微血管减少。沉默信息调节因子1(SIRT1)是一种依赖烟酰胺腺嘌呤二核苷酸的去乙酰化酶,在器官损伤和纤维化中表达显著下调,参与调节细胞的氧化应激、炎症、凋亡及自噬等过程,与肾间质纤维化的发生和发展关系密切。目前,通过激活SIRT1来预防和治疗组织纤维化已成为一大研究热点。随着SIRT1与肾纤维化关系研究的不断深入,未来SIRT1有望成为预防和治疗肾纤维化的新靶点。Renal fibrosis,especially tubular renal interstitial fibrosis,is the pathological basis of various chronic kidney diseases to end-stage renal disease,and it is also a reliable predictor of the prognosis of renal insufficiency.Cell dysfunction caused by renal oxidative stress,apoptosis and inflammation will further aggravate renal tissue damage,and this process is closely related to renal fibrosis,mainly manifested as glomerular sclerosis,renal interstitial fibrosis,the accumulation of extracellular matrix and the reduction of capillaries.Silent information regulator 1(SIRT1)is a deacetylase that depends on nicotinamide adenine dinucleotide.Its expression is significantly down-regulated in organ damage and fibrosis.It participates in the regulation of cell oxidative stress,inflammation,apoptosis and autophagy,and is involved in the occurrence and development of renal interstitial fibrosis.At present,the prevention and treatment of tissue fibrosis by activating SIRT1 has become a major research hotspot.With the deepening of the research on the relationship between SIRT1 and renal fibrosis,SIRT1 is expected to become a new target for the prevention and treatment of renal fibrosis in the future.

关 键 词：纤维化 沉默信息调节因子1 肾纤维化 

分 类 号：R692.2[医药卫生—泌尿科学]