经血源性子宫内膜干细胞治疗宫腔粘连的研究进展  

Research Progress of Menstrual Blood-derived Stem Cells in Treatment of Intrauterine Adhesion

作　　者：任志帅 马沈倩 王瑞雅 刘畅 杨舒文 黄慧宁 岑娟 郭玉琪 REN Zhishuai;MA Shenqian;WANG Ruiya;LIU Chang;YANG Shuwen;HUANG Huining;CEN Juan;GUO Yuqi(Department of Gynecology,People's Hospital of Zhengzhou University/Henan Provincial People's Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院河南省人民医院妇产科,郑州450003

出　　处：《医学综述》2022年第8期1555-1560,共6页Medical Recapitulate

基　　金：河南省高等学校重点科研项目计划基础研究专项(20zx011);河南省科技厅科技攻关项目(212102310042,212102310045)。

摘　　要：宫腔粘连也被称为Asherman综合征,是涉及医源性宫腔手术的子宫内膜损伤的结果。严重的宫腔粘连可能损伤子宫内膜的基底层,影响子宫内膜上皮细胞和损伤血管的再生,从而导致子宫内膜修复障碍。由于机制不清,大大限制了宫腔粘连治疗的发展。近年来,干细胞治疗在组织再生和重建中显示出良好的前景。而经血源性子宫内膜干细胞在子宫内膜再生中展现了区别于其他类型干细胞的独特优势。基于经血源性子宫内膜干细胞的宫腔粘连治疗策略可能是解决宫腔粘连问题的关键,具有广阔的应用前景。Intrauterine adhesion,also known as Asherman syndrome,is the result of endometrial injury related to iatrogenic uterine surgery.Severe intrauterine adhesion may damage the basal layer of endometrium,affect the regeneration of endometrial epithelial cells and damaged blood vessels,and thus lead to endometrial repair disorders.Because ther mechanism is still unclear,the development of treatment for intrauterine adhesions is greatly limited.In recent decades,stem cell therapy has shown good prospects in tissue regeneration and reconstruction.Menstrual blood-derived stem cells show unique advantages different from other types of stem cells in endometrial regeneration.The treatment strategy of intrauterine adhesion based on menstrual blood-derived stem cells may be the key to solve the problem and has broad applicative prospects.

关 键 词：宫腔粘连 经血源性子宫内膜干细胞 子宫内膜损伤 干细胞治疗 修复 

分 类 号：R711[医药卫生—妇产科学]