铁调素在川崎病患儿中的研究进展  

Research Progress of Hepcidin in Children with Kawasaki Disease

作　　者：马姣 陈钰波 李宇宁[2] MA Jiao;CHEN Yubo;LI Yuning(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Department of Pediatrics,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院儿科,兰州730000

出　　处：《医学综述》2022年第8期1579-1584,共6页Medical Recapitulate

摘　　要：川崎病是一种急性、发热性、血管炎性疾病,累及全身各个系统,可导致贫血及冠状动脉损害。铁调素是一种急性时相反应蛋白,在调节铁稳态中发挥至关重要的作用。铁调素在川崎病患儿的贫血、冠状动脉损害及静脉注射免疫球蛋白治疗无反应中占据重要地位,这为通过抑制铁调素的产生进而预防贫血、冠状动脉损害发生以及改善静脉注射免疫球蛋白治疗无反应性、减少川崎病患儿并发症的发生等提供了理论依据。未来,铁调素在川崎病患儿的临床诊断及治疗中具有很好的应用前景。Kawasaki disease,as an acute,febrile,vasculitis disease,affects all systems of the body,and can also lead to anemia and coronary artery damage.Hepcidin is a type of acute phase reaction protein that plays a crucial role in regulating the steady state of iron.Hepcidin plays an important role in anemia,coronary artery damage and the non-response of intravenous immunoglobulin therapy in Kawasaki disease,which provides theoretical basis for preventing anemia and coronary artery damage,improving non-response of intravenous immunoglobulin therapy,and reducing the incidence of complications in patient with Kawasaki disease through inhibiting the generation of hepcidin.In the future,hepcidin will have a good applicative prospect in the clinical diagnosis and treatment of children with Kawasaki disease.

关 键 词：川崎病 铁调素 炎症性贫血 冠状动脉损害 儿童 

分 类 号：R725.4[医药卫生—儿科]