微波消解-电感耦合等离子体质谱法测定参苓白术散中重金属及有害元素含量  

Determination of Heavy Metals and Harmful Elements in Shenling Baizhu Powder with Miccorowave Digestion-ICP-MS

作　　者：邵大志[1] 张亦萌 张强 曲涵婷 程焱 李正刚 马彧[1] SHAO Dazhi;ZHANG Yimeng;ZHANG Qiang;QU Hanting;CHENG Yan;LI Zhenggang;MA Yu(Siping Institute for Food and Drug Control,Siping Jilin,13600,China;Siping Social Psychiatric Hospital)

机构地区：[1]四平市食品药品检验所,吉林四平136000 [2]四平市社会精神病院

出　　处：《质量安全与检验检测》2022年第2期21-23,共3页QUALITY SAFETY INSPECTION AND TESTING

基　　金：吉林省科技厅-医药健康领域-重点研发项目(20210204151YY)。

摘　　要：本文建立了参苓白术散中铅、砷、汞、镉、铜5种重金属及有害元素的含量测定方法。样品经微波消解后,采用电感耦合等离子体质谱(ICP-MS)测定5种金属元素的含量,以锗(^(72)Ge)、铟(^(115)In)、铋(^(209)Bi)混合溶液作为内标。结果显示,铅、砷、汞、镉、铜5种待测元素的线性关系良好(r≥0.9994),回收率在92.4%~103.8%(RSD<5.3%),方法检出限在0.019~0.036 mg/kg。由此可见,方法灵敏度高,准确可靠。5批样品均不同程度的检出了铅、砷、汞、镉、铜,但均在安全限度之内。To establish an ICP-MS method for the determination of 5 kinds of heavy metals and harmful elements including copper,arsenic,cadmium,mercury and lead in Shenling baizhu powder.The samples digested by icrowave and then inductively coupled plasma mass spectrometry(ICP-MS)was used to determine the mass concentration of 5 metal elements.^(72)Ge,^(115)In,^(209)Bi were used as internal standards.The results show that,the 5 kinds of heavy metals and harmful elements showed good linearity within the selected concentration ranges(r≥0.9994)with the recovery from 92.3%to 103.8%,while their RSD were below 5.3%.The detection limits of the method were range from 0.019-0.036 mg/kg,Thus it can be seen,the method is accurate and sensitive.5 batches of samples contained different levels of Pb,As,Hg,Cd and Cu,but within safe limits.

关 键 词：参苓白术散 重金属及有害元素 微波消解 电感耦合等离子体质谱 

分 类 号：R917[医药卫生—药物分析学]