内分泌系统疾病的肝脏表现  

Liver involvement in endocrine diseases

作　　者：王倩怡[1] 欧晓娟[1] 贾继东[1] Wang Qianyi;Ou Xiaojuan;Jia Jidong(Liver Research Center,Beijing Friendship Hospital,Capital Medical University Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis&National Clinical Research Center for Digestive Diseases,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院肝病中心北京市肝硬化转化医学重点实验室国家消化系统疾病临床医学研究中心,北京100050

出　　处：《中华肝脏病杂志》2022年第4期352-356,共5页Chinese Journal of Hepatology

基　　金：北京市医院管理局消化内科学科协同发展中心消化专项重点项目(XXZ0304)。

摘　　要：肝脏作为次级内分泌器官,与整个内分泌系统之间存在密切联系。多种内分泌系统疾病可影响到肝脏,如甲状腺功能亢进/减退症、糖尿病、肾上腺、性腺相关疾病等,并可表现为肝细胞损伤(转氨酶升高)、胆管损伤(胆汁淤积)、肝细胞脂肪变性、血管损伤及肝占位等多种形式。激素水平异常引起的直接、间接肝损伤、治疗内分泌疾病药物的不良反应是其常见的机制。此外,内分泌疾病可同时合并肝脏疾病如自身免疫性甲状腺炎易合并自身免疫性肝炎;全身系统性疾病也可同时累及内分泌系统和肝脏,如系统性红斑狼疮、IgG4相关疾病等。临床上遇到不明原因肝损伤的患者,需注意内分泌系统疾病的甄别。As a secondary endocrine organ,the liver is closely related to the endocrine system.Liver involvement is not uncommon in endocrine diseases,such as hyper/hypothyroidism,diabetes,dysfunction of adrenal and gonadal.It can be manifested in a variety of forms,including hepatocyte injury(elevated transaminase),bile duct injury(cholestasis),hepatocyte steatosis,vascular injury and liver tumor.Direct and indirect liver injury caused by abnormal hormone levels and side effects of drugs for the treatment of endocrine diseases are common pathogenesis.In addition,endocrine diseases can be concomitant with liver diseases,such as autoimmune thyroiditis and autoimmune hepatitis.Systemic diseases can also involve the endocrine system and liver at the same time,such as systemic lupus erythematosus and IgG4 related diseases.For patients with unexplained liver injury,endocrine system diseases should be considered as the differential diagnosis.

关 键 词：内分泌系统 内分泌病 胆汁淤积 肝细胞损伤 肝细胞脂肪变性 

分 类 号：R58[医药卫生—内分泌] R575[医药卫生—内科学]