针对脓毒症炎性反应机制进行中药防治的研究进展  

Research Progress of Traditional Chinese Medicine on Prevention and Treatment of Sepsis in Flammatory Response

作　　者：闫中博(综述) 张楠 杨贯彤 郭亚雄(审校)[1] YAN Zhong-bo;ZHANG Nan;YANG Guan-tong;GUO Ya-xiong(Institute of Microcirculation, Hebei North University, Key Laboratory of Microcirculation and Shock in Zhangjiakou City, Zhangjiakou 075000, China)

机构地区：[1]河北北方学院微循环研究所,张家口市微循环与休克重点实验室,张家口075000

出　　处：《微循环学杂志》2022年第2期61-66,共6页Chinese Journal of Microcirculation

基　　金：河北省自然科学基金资助项目(H2021405030);2021年河北北方学院校级科研项目(XJ2021024)。

摘　　要：脓毒症是机体对感染反应失调导致的急性器官功能障碍,具有高发病率、高死亡率的特征,寻找有效的治疗药物一直是脓毒症防治的研究重点之一。中医药对脓毒症的防治具有一定的疗效,特别是其抗炎作用备受关注。中药如大黄、黄芪、姜黄素、黄连等能有效减少炎性细胞和炎症因子的形成,抑制相应信号通路的激活,从而改善脓毒症症状,提高治疗效果。本文综述脓毒症的炎症反应机制及当前相关中药在其中作用的最新研究进展,期望为传统中药应用于脓毒症治疗拓展新的思路。Sepsis is an acute organ dysfunction caused by the activation of inflammatory cells and the release of related inflammatory mediators,with high morbidity and high mortality rates.Therefore,to search for effective anti-inflammatory drugs has always been a key point in sepsis.Chinese medicine has the anti-inflammatory effect,and has attracted much attention on sepsis.Rhubarb,astragalus,curcumin,coptis etc.can effectively reduce the formation of inflammatory cells and inflammatory factors,inhibit the activation of corresponding signaling pathways,improve the therapeutic effect.This review focuses on the inflammatory response mechanism of sepsis and the latest research progress on the role of related traditional Chinese medicine in it.It expands new ideas for the application of traditional Chinese medicine in the treatment of sepsis.

关 键 词：脓毒症 炎症细胞 中药疗法 

分 类 号：R631.2[医药卫生—外科学]