焦亡在脊髓损伤中的作用机制及临床研究进展  

Mechanism and clinical research progress of pyroptosis in spinal cord injury

作　　者：赵艺 贾延劼[1] Zhao Yi;Jia Yanjie(Department of Neurology,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,郑州450052

出　　处：《中华神经医学杂志》2022年第4期409-413,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金 (U1604170)。

摘　　要：大量研究表明焦亡相关分子在脊髓损伤(SCI)动物模型中表达上调,通过抑制焦亡减轻神经炎症将是治疗SCI的新途径。本文围绕焦亡在SCI中的作用机制及其临床应用进行综述,以期为SCI治疗提供参考和借鉴。A large number of studies have shown that the expressions of pyroptosis-related molecules are up-regulated in spinal cord injury(SCI)animal models.Neuroinflammation alleviation by inhibiting pyroptosis will be a new target for treating SCI.This article reviews the mechanism and clinical application of pyroptosis in SCI,in order to provide references for SCI treatment.

关 键 词：脊髓损伤 焦亡 炎性小体 

分 类 号：R651.2[医药卫生—外科学]