α7烟碱型乙酰胆碱能受体介导的胆碱能系统对动脉粥样硬化疾病的影响  

Effect of α7 nicotinic acetylcholine receptor mediated cholinergic system on atherosclerosis

作　　者：孙美玲[1] 曲文博 田进伟[1] Sun Meiling;Qu Wenbo;Tian Jinwei(Department of Cardiology,the 2nd Affiliated Hospital of Harbin Medical University,the Key Laboratory of Myocardial Ischemia,Chinese Ministry of Education,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院心内科心肌缺血教育部重点实验室,150086

出　　处：《中国心血管杂志》2022年第2期200-203,共4页Chinese Journal of Cardiovascular Medicine

基　　金：国家十三五重点研发计划项目(2016YFC1301300);国家十三五重点研发计划课题(2016YFC1301300、2016YFC1301302、2016YFC1301304);广西糖尿病系统医学重点实验室开放课题(GKLCDSM-20200101-01)。

摘　　要：胆碱能抗炎通路是神经系统介导免疫反应的重要通路,其中,α7烟碱型乙酰胆碱能受体(α7nAChR)发挥关键作用。存在于免疫细胞、内皮细胞、平滑肌细胞上的非神经元性α7nAChR在动脉粥样硬化疾病进展和病理形成过程中发挥重要作用,本文就α7nAChR与动脉粥样硬疾病的关系作一总结。The cholinergic anti-inflammatory pathway is an important pathway for the nervous system mediated immune response,among which α7 nicotinic acetylcholine receptor(α7 nAChR) plays a key role.Non-neuronal α7 nAChR,which exists in immune cells,endothelial cells and smooth muscle cells,plays an important role in the progression and pathogeny of atherosclerotic diseases.This article summarizes the relationship between α7 nAChR and atherosclerotic diseases.

关 键 词：动脉粥样硬化 胆碱能抗炎通路 α7烟碱型乙酰胆碱能受体 

分 类 号：R543.5[医药卫生—心血管疾病]