自拟鳖甲软肝汤联合化疗治疗原发性肝癌临床评价  

Clinical Evaluation of Self-Made Biejia Ruangan Decoction Combined with Chemotherapy in the Treatment of Primary Liver Cancer

作　　者：张长征 苗秀英[1] 宋来成[1] ZHANG Changzheng;MIAO Xiuying;SONG Laicheng(Taihe TCM Hospital Affiliated to Anhui University of Traditional Chinese Medicine,Fuyang,Anhui,China 236600)

机构地区：[1]安徽中医药大学附属太和县中医院,安徽阜阳236600

出　　处：《中国药业》2022年第10期103-106,共4页China Pharmaceuticals

基　　金：国家科技重大专项合作项目[2018ZX10725-506]。

摘　　要：目的探讨自拟鳖甲软肝汤联合化学药物治疗(简称化疗)对原发性肝癌的临床疗效。方法选取医院2016年6月至2019年6月收治的原发性肝癌患者180例,根据治疗方案的不同分为观察组(95例)和对照组(85例)。两组患者均予FOLFOX方案行常规肝癌化疗,观察组患者加服鳖甲软肝汤。两组均以2周为1个周期,连续治疗3个周期。结果观察组的客观缓解率及疾病控制率分别为70.53%及81.05%,显著高于对照组的52.94%及64.71%(P<0.05);与对照组比较,观察组患者治疗后的腹痛、腹胀、纳呆、乏力等中医证候评分均显著降低,丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、碱性磷酸酶、总胆红素水平均显著降低,波形蛋白、高尔基体跨膜糖蛋白73、GATA锌指转录因子6水平均显著降低(P<0.05);观察组与对照组不良反应发生率相当(10.53%比8.24%,P>0.05)。结论鳖甲软肝汤联合化疗治疗原发性肝癌,能改善患者的中医证候,降低其肝功能指标和肝癌血清标志物水平。Objective To investigate the clinical efficacy of self-made Biejia Ruangan Decoction combined with chemotherapy in the treatment of primary liver cancer.Methods A total of 180 patients with primary liver cancer admitted to the hospital from June 2016 to June 2019 were selected and divided into the observation group(95 cases)and the control group(85 cases)according to different treatment regimens.The patients in the two groups were treated with routine FOLFOX regimen for liver cancer chemotherapy,on this basis,the patients in the observation group were treated with Biejia Ruangan Decoction.Both groups were treated for three consecutive cycles with two weeks as a cycle.Results The objective remission rate(ORR)and disease control rate(DCR)in the observation group were 70.53%and 81.05%,which were significantly higher than 52.94%and 64.71%in the control group(P<0.05).Compared with those in the control group,the scores of traditional Chinese medicine(TCM)syndromes such as abdominal pain,abdominal distension,stupidity and fatigue in the observation group decreased significantly after treatment(P<0.05),and the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and total bilirubin(TBiL)in the observation group decreased significantly(P<0.05),the levels of vimentin(VIM),Golgi transmembrane glycoprotein 73(gp-73)and GATA zinc finger transcription factor 6(GATA6)in the observation group decreased significantly(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(10.53%vs.8.24%,P>0.05).Conclusion Biejia Ruangan Decoction combined with chemotherapy in the treatment of primary liver cancer can improve the TCM syndromes of patients,and reduce the index of liver function and the level of serum markers of liver cancer.

关 键 词：原发性肝癌 鳖甲软肝汤 化学治疗 肝功能指标 血清标志物 

分 类 号：R969.4[医药卫生—药理学] R932[医药卫生—药学]