银屑病合并2型糖尿病的研究进展  

Research progress of psoriasis complicated with type 2 diabetes mellitus

作　　者：刘聪颖 潘俊宏 毛逸伦 文松 王聪聪 许程琳 李秀财 徐冬香 周里钢 Liu Congying;Pan Junhong;Mao Yilun;Wen Song;Wang Congcong;Xu Chenglin;Li Xiucai;Xu Dongxiang;Zhou Ligang(Department of Endocrinology,Shanghai Pudong Hospital/Fudan University Pudong Medical Center)

机构地区：[1]上海市浦东医院/复旦大学附属浦东医院内分泌科,上海201399

出　　处：《重庆医科大学学报》2022年第4期484-488,共5页Journal of Chongqing Medical University

基　　金：国家自然科学基金面上资助项目(编号:81370932);浦东新区中西医重点专科资助项目(编号:PWZzK2017-03)。

摘　　要：银屑病是一种常见的慢性炎症性皮肤病。糖尿病是一组由于胰岛素分泌绝对或相对缺陷,以及胰岛素抵抗所引起的以慢性高血糖为特征的代谢性疾病。目前流行病学研究认为,银屑病患者较一般人群发生糖尿病的风险显著增高。银屑病患者体内肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平明显增高,而TNF-α在胰岛素抵抗中发挥重要作用。目前发现CDKAL1、PSORS2、PSORS3和PSORS4这4个银屑病易感基因与2型糖尿病相关。既往研究提示,一些降糖药物如噻唑烷二酮类药物在治疗2型糖尿病的同时,可能通过改变皮下慢性炎症状态而改善银屑病皮损症状。本文总结相关研究进展,并分析与2种疾病相联系的可能病理生理学机制及相关治疗。Psoriasis is a common chronic inflammatory skin disease. Diabetes is a group of metabolic diseases characterized by chronic hyperglycemia due to absolute or relative deficiencies in insulin secretion and insulin resistance. Current epidemiological studies indicate that patients with psoriasis have a significantly higher risk of developing diabetes than the general population. Patients with psoriasis have significantly higher levels of tumor necrosis factor-α(TNF-α) which plays an important role in insulin resistance. It has been found that four susceptible genes of psoriasis,CDKAL1,PSORS2,PSORS3 and PSORS4,are related to type 2 diabetes mellitus. In addition,our previous studies suggested that an hypoglycemicdrug,thiazolidinediones,can also improve the psoriasis skin lesion symptoms by changing the hypodermic chronic inflammatory state while treating the type 2 diabetes mellitus.Therefore, this paper summarizes the relevant research progress,analyzes the possible pathophysiological mechanisms,and related therapies for these two diseases.

关 键 词：银屑病 2型糖尿病 发病机制 药物治疗 

分 类 号：R587.1[医药卫生—内分泌]