维生素D与妊娠期糖尿病的研究进展  

Research progress on Vitamin D deficiency and gestational diabetes mellitus

作　　者：韩晓文[1] 孙桢[1] 李雪姣[1] 邢丽[1] Han Xiaowen;Sun Zhen;Li Xuejiao;Xing Li(Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100)

机构地区：[1]天津市中心妇产科医院,天津300100

出　　处：《天津药学》2022年第2期72-78,共7页Tianjin Pharmacy

基　　金：天津市卫健委科技人才培育项目(No.KJ20208)。

摘　　要：妊娠期糖尿病(GDM)指妊娠期发生的不同程度的糖代谢异常,近年来发病率不断升高,严重危害母婴健康,增加不良妊娠结局的发生。维生素D可调节钙、磷代谢,促进骨骼生长,调节细胞生长分化,还可改善血糖代谢及胰岛素抵抗。研究发现,人群中普遍存在维生素D缺乏,孕妇更易出现,而维生素D的缺乏会使孕妇发生GDM的风险增高。妊娠期间补充维生素D可能对于预防及治疗GDM有一定的效果,但是对于妊娠结局的影响以及维生素D的补充剂量尚无统一的定论,本文对维生素D与GDM的相关研究进展进行综述,为GDM的预防和治疗提供参考。Gestational diabetes mellitus(GDM)refers to the abnormal glucose metabolism of different degrees during pregnancy.In recent years,the incidence of GDM has been increasing which can seriously affect maternal and infant health and increase the occurrence of adverse pregnancy outcomes.Vitamin D can regulate metabolism of calcium and phosphorus,promote bone growth,adjust the cell growth,and improve glucose metabolism and insulin resistance.Studies reveal that Vitamin D deficiency is common in the population,which is more common in pregnant women,and Vitamin D deficiency will increase the risk of developing GDM in pregnant women.Vitamin D supplementation during pregnancy may have a certain effect on the prevention and treatment of GDM,but there is no unified conclusion on the impact of pregnancy outcome and the supplement dose of Vitamin D.This paper will summarize the relevant research progress on Vitamin D deficiency and GDM,so as to provide reference for the prevention and treatment of GDM.

关 键 词：妊娠期糖尿病 维生素D缺乏 胰岛素抵抗 

分 类 号：R977.24[医药卫生—药品] R587[医药卫生—药学]