重庆地区献血人群Kidd、Duffy、MNS、Kell、Diego血型系统的低频抗原分布频率  

Distribution frequency of low-frequency antigen in Kidd,Duffy,MNS,Kell and Diego blood group systems among blood donors,Chongqing area

作　　者：蒋玉林 刘不尽[1] 邹晓萍[1] 邹海曼 黄文娟 卿芸 王芳[1] 毛伟[1] JIANG Yulin;LIU Bujin;ZOU Xiaoping;ZOU Haiman;HUANG Wenjuan;QING Yun;WANG Fang;MAO Wei(Institute of Blood Transfusion,Chongqing Blood Center,Chongqing 400052,China)

机构地区：[1]重庆市血液中心输血研究所,重庆400052

出　　处：《中国输血杂志》2022年第4期435-437,共3页Chinese Journal of Blood Transfusion

基　　金：重庆市科卫联合医学科研项目(2018MSXM060)。

摘　　要：目的了解重庆地区献血者中的红细胞稀有血型表型分布频率特点,为建立本地区稀有血型供者资料库提供基础数据。方法采用尿素溶血试验对重庆市血液中心2020年12月~2021年5月的14805(人)份无偿献血者标本做Kidd血型系统的Jk(a-b-)表型筛选,并用盐水凝集试验对筛选样本做确认试验;采用间接抗球蛋白试验对1466(人)份O型献血者标本做Duffy血型系统Fy(a-)、MNS血型系统s-及Kell血型系统k-表型筛选;采用凝聚胺试验对856(人)份献血者标本做Diego血型系统Di(b-)表型筛选,并用抗球蛋白试验确认。结果重庆地区无偿献血者中Jk(a-b-)表型比例0.0203%(3/14805);O型献血者中的Fy(a-b+)及S+s-表型比例均为0.1364%(2/1466);未见k-表型;Di(a+b-)表型的比例为0.2336%(2/856)。结论重庆地区献血人群上述5个血型系统的稀有血型抗原分布频率有自身地域特点。Objective To investigate the distribution frequency of RBC rare blood group among blood donors in Chongqing,so as to provide basic data for the establishment of regional rare blood group donor database.Methods A total of 14805 voluntary blood donors of Chongqing Blood Center from December 2020 to May 2021 were screened for Jk(a-b-)phenotype of Kidd blood group system by urea hemolysis test and confirmed by saline agglutination test.The indirect anti-globulin test was used to screen the Fy(a-)phenotype of Duffy blood group system,s-phenotype of the MNS blood group system and k-phenotype of Kell blood group system in 1466 O type blood donors.The polyamine test was used to screen the Di(b-)phenotype of Diego blood group system in 856 voluntary blood donors,and confirmed by anti-globulin test.Results Among the voluntary blood donors in Chongqing,the proportion of Jk(a-b-)phenotype was 0.0203%(3/14805).The ratio of both Fy(a-b+)and S+s-phenotype among type O blood donors was 0.1364%(2/1466),and k-phenotype was not seen.The proportion of Di(a+b-)phenotype among 856 blood donors was 0.2336%(2/826).Conclusion The distribution frequency of rare blood group antigens in the above five blood group systems in Chongqing voluntary blood donors presents regional characteristics.

关 键 词：稀有血型 红细胞 低频抗原频率 重庆 无偿献血者 

分 类 号：R457.11[医药卫生—治疗学]