沙丁胺醇联合白三烯受体拮抗剂对高龄老年咳嗽性哮喘的疗效及对免疫功能的影响  

Effects of Salbutamol Combined with Leukotriene Receptor Antagonist on Cough Variant Asthma and Immune Function in Older Patients

作　　者：郭丽 王娟 周菁 Guo Li;Wang Juan;Zhou Jing(Air Force 986 Hospital,Xi'an 710054)

机构地区：[1]空军第九八六医院,西安710054

出　　处：《国际老年医学杂志》2022年第3期268-272,共5页International Journal of Geriatrics

基　　金：国家自然科学基金项目(81674081)。

摘　　要：目的研究沙丁胺醇联合白三烯受体拮抗剂对高龄老年咳嗽性哮喘的疗效及对免疫功能的影响。方法选取2017年9月〜2019年9月临床确诊的高龄老年咳嗽性哮喘患者100例作为研究对象,按照随机数字表法将所有患者分为拮抗剂组和联合组各50例,拮抗剂组使用白三烯受体拮抗剂孟鲁司特钠治疗,联合组在拮抗剂组基础上使用沙丁胺醇治疗,对两组临床症状恢复时间、肺功能、转化生长因子β1(TGF-β1)、肿瘤坏死因子α(TNF-α)、血清免疫球蛋白(IgE)水平、免疫功能进行检测,并统计两组治疗效果及不良反应发生情况。结果联合组体温恢复正常时间、哮喘控制时间及肺部症状消失时间均低于拮抗剂组(P<0.05),治疗后联合组FEV1,FEV1/FVC及PEF高于拮抗剂组(P<0.05),治疗后联合组TGF-β1水平高于拮抗剂组,TNF-α、IgE水平低于拮抗剂组(P<0.05),治疗后联合组患者CD4^(+)、CD4^(+)/CD8^(+)高于拮抗剂组,CD8^(+)低于拮抗剂组(P<0.05);联合组治疗总有效率以及不良反应发生率均高于拮抗剂组,但差异无统计学意义(P>0.05)。结论沙丁胺醇联合白三烯受体拮抗剂对老年咳嗽性哮喘疗效显著,能够显著改善患者炎性因子水平,提高患者免疫功能及肺功能,具有较好的安全性,值得临床推广。Objective To study the effects of salbutamol combined with leukotriene receptor antagonist on cough variant asthma and immune function in older patients.Methods A total of 100 older patients with cough variant asthma from September 2017 to September 2019 were included in this study.The patients were divided into the antagonist group(50 cases)and the combination group(50 cases).The antagonist group was treated with leuktetriene receptor antagonist montelukast sodium.The combination group was treated with montelukast sodium and salbutamol.The recovery time of clinical symptoms,lung function,the levels of transforming growth factor β1(TGF-β1),tumor necrosis factor-α(TNF-α),serum IgE,and immune function were determined.The treatment effect and adverse effects in the two groups were recorded.Results In the combination group,the recovery time of body temperature,the control time of asthma and the disappearance time of pulmonary symptoms were shorter than those in the antagonist group(P<0.05).After treatment,forced expiratory volume in the first second(FEV1),FEV1/forced vital capacity(FVC)and peak expiratory flow(PEF)were higher in the combination group than those in the antagonist group(P<0.05).TGF-β1 level was higher in the combination group than that in the antagonist group,while the levels of TNF-αand IgE were lower than those in the antagonist group(P<0.05).The proportion of CD4^(+) and CD4^(+)/CD8^(+) in the combination group were higher than those in the antagonist group,while the proportion of CD8^(+) was lower than that in the antagonist group,there were significant differences between the two groups(P<0.05).The overall response rate and the incidence of adverse reactions in the combination group were higher than those in the antagonist group,but there were no significant differences between the two groups(P>0.05).Conclusion Salbutamol combined with leukotriene receptor antagonists has a significant therapeutic effect on cough variant asthma by improving the levels of inflammatory factors and enhancing th

关 键 词：沙丁胺醇 白三烯受体拮抗剂 老年咳嗽性哮喘 免疫功能 

分 类 号：R562.25[医药卫生—呼吸系统]