自由基致衰老的研究进展  

Research progress of free radical induced aging

作　　者：杨善岚 吴磊[1] 涂嘉欣 邓莉芳 黄河浪[1] YANG Shan-lan;WU Lei;TU Jia-xin;DENG Li-fang;HUANG He-lang(School of Public Health of Nanchang University,Jiangxi Province Key Laboratory of Preventive Medicine,Nanchang 330006,China)

机构地区：[1]南昌大学公共卫生学院,江西省预防医学重点实验室,南昌330006

出　　处：《中华疾病控制杂志》2022年第5期589-594,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81960620,81360446)。

摘　　要：1954年Harman首次提出的自由基致衰老理论(free radical theory of aging,FRTA)认为,环境和内部代谢产生的自由基会对细胞成分造成损害,进而造成人体功能的损害,加速衰老。人体衰老研究发展迅速,学说众多,争论较大,但自由基理论一直受到广泛关注,多数文献肯定了自由基在致衰老、诱导某些慢性病发生方面的作用。本文从生物医学、分子病理学、流行病学等层面概括性地阐述了自由基的内涵与致病机制,重点介绍了近些年自由基研究的新进展以及与传统认识的差距。同时,本文提出了自由基致衰老的可能路径:自由基持续、动态、循环的作用于机体,当打破某种循环平衡时,衰老才可能发生。该路径为人群预防衰老、延缓衰老减少慢性病等工作带来了机遇与思考。The theory of free radical-induced aging(FRTA),first proposed by Denham Harman in 1954,believes that free radicals generated in the environment and from internal metabolism can damage cell components,thus damaging human function and accelerating aging.The research of human aging has developed rapidly,there are many theories and great debates,but the free radical theory has drawn wide attention.Most works of literature have given this theory some academic support as they affirm the fact that free radicals can cause aging and induce some chronic diseases.This paper summarizes the connotation and pathogenesis of free radicals from the aspects of biomedicine,molecular epidemiology and epidemiology,focuses on the progress of research on free radical in recent years and reveals the gap between the traditional understanding.At the same time,the paper puts forward a possible path of free radical-induced aging:free radicals act on the body continuously,dynamically and circularly.Aging can only occur when a certain cyclic balance is broken.This path brings opportunities and thoughts on preventing aging,reducing chronic diseases and delaying aging.

关 键 词：衰老 自由基 氧化 适应性 

分 类 号：R181[医药卫生—流行病学]