补肾活血方治疗多囊卵巢综合征导致排卵障碍性不孕症肾虚血瘀证患者的疗效研究  

Clinical Efficacy of Bushen Huoxue Formula on Ovulatory Infertility Caused by Polycystic Ovary Syndrome(Kidney Deficiency and Blood Stasis Syndrome)

作　　者：娄冬梅 郭贺龙 LOU Dong-mei;GUO He-long(Laboratory Department of Tongzhou Maternal and Child Health Care Hospital of Beijing,Beijing101101;Tongzhou District Central Blood Station of Beijing Municipality,Beijing101117)

机构地区：[1]北京市通州区妇幼保健院检验科,北京101101 [2]北京市通州区中心血站,北京101117

出　　处：《世界中西医结合杂志》2022年第3期561-565,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：北京市通州卫生发展科研专项项目(TFZXPT-20180121)。

摘　　要：目的 观察补肾活血方对肾虚血瘀型多囊卵巢综合征(Polycystic ovarian syndrome, PCOS)导致排卵障碍性不孕症患者卵巢功能及生殖内分泌指标的影响。方法 选取2018年6月—2019年12月期间北京市通州区妇幼保健院收治的PCOS致排卵障碍性不孕症患者100例,随机分为观察组和对照组,每组各50例。对照组给予常规西药治疗,观察组在对照组治疗基础上给予补肾活血方治疗。连续治疗3个月经周期后,观察比较两组患者治疗前后卵巢功能(卵泡个数、最大卵泡直径、子宫内膜厚度)和生殖内分泌指标[卵泡生成素(Follicle-stimulating hormone, FSH)、促黄体生成素(Luteinizing hormone, LH)/FSH、睾酮(Testosterone, T)]改善状况,比较两组临床疗效、排卵状况、妊娠状况及不良反应发生情况。结果 治疗后两组患者卵泡个数均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组降低更为明显,差异有统计学意义(P<0.05)。治疗后两组患者最大卵泡直径、子宫内膜厚度均较治疗前明显升高,差异有统计学意义(P<0.05);且观察组升高更为明显,差异有统计学意义(P<0.05)。两组患者治疗后血清LH、LH/FSH、T水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组降低更为明显,差异有统计学意义(P<0.05)。治疗后观察组排卵率为64.0%,妊娠率为38.0%,明显高于对照组排卵率38.0%、妊娠率20.0%,两组比较差异有统计学意义(P<0.05)。治疗后观察组总有效率为92.0%(46/50),明显高于对照组76.0%(38/50),差异有统计学意义(P<0.05)。治疗期间,两组患者血常规、尿常规、大便常规及肝肾功能指标均未出现明显异常变化,均未发生药物相关不良反应。结论 补肾活血方能够调节肾虚血瘀型多囊卵巢综合征导致排卵障碍性不孕症患者生殖内分泌功能,改善卵巢功能,有助于提高患者排卵和妊娠率。Objective To observe the clinical efficacy of Bushen Huoxue Formula on ovarian function and reproductive endocrine indexes in patients with ovulatory infertility caused by polycystic ovary syndrome(PCOS)with kidney deficiency and blood stasis syndrome.Methods A total of 100 patients with PCOS-induced ovulatory infertility admitted to Tongzhou Maternal and Child Health Care Hospital of Beijing from June 2018 to December 2019 were randomly divided into a control group(50)and an observation group(50).All patients were treated by conventional western medicine, while those in the observation group received additional oral Bushen Huoxue Formula.All patients were treated for three menstrual cycles.The ovarian functions(number of follicles, maximum follicular diameter, and endometrial thickness),and reproductive endocrine indexes[follicle-stimulating hormone(FSH),luteinizing hormone(LH)/FSH,and testosterone(T)]of the two groups before and after treatment were observed.The clinical efficacy, ovulation, pregnancy, and adverse events were compared between the two groups.Results After treatment, the number of follicles in the two groups decreased(P<0.05),and the reduction in the observation group was more significant(P<0.05).The post-treatment maximum follicular diameterand endometrial thickness in both groups increased as compared with those before treatment(P<0.05),and the increasein the observation group was more significant(P<0.05).The post-treatment serum levels of LH,LH/FSH,and T were lower than those before treatment(P<0.05),especially in the observation group(P<0.05).The ovulation rate and the pregnancy rateof the observation group were 64.0% and 38.0%,higher than 38.0%and 20.0% of the control group, respectively(P<0.05).The total effective rate in the observation group was 92.0%,higher than 76.0% in the control group(P<0.05).During the treatment, no obvious abnormalities in blood routine, urine routine, stool routine examinations, and liver and kidney function indexes were observed in the two groups, and no drug-rel

关 键 词：多囊卵巢综合征 排卵障碍性不孕症 肾虚血瘀型 补肾活血方 卵巢功能 生殖内分泌功能 妊娠率 排卵率 

分 类 号：R271.14[医药卫生—中医妇科学]