加巴喷丁联合透明质酸钠对膝关节骨性关节炎患者疼痛和血清β-内啡肽、前列腺素E_(2)水平的影响  

Effect of Gabapentin Combined with Sodium Hyaluronate on Pain,Serumβ-Endorphin and Prostaglandin E2 in Patients with Knee Osteoarthritis

作　　者：张强[1] 周飞[1] 常睿 郑娜[3] ZHANG Qiang;ZHOU Fei;CHANG Rui(Department of Orthopedics,Yan'an People's Hospital,Yan'an,Shaanxi,716000)

机构地区：[1]延安市人民医院骨科,陕西延安716000 [2]延安大学附属医院高压氧科,陕西延安716000 [3]延安大学附属医院肾内科,陕西延安716000

出　　处：《医学临床研究》2022年第4期503-506,共4页Journal of Clinical Research

摘　　要：【目的】探讨加巴喷丁联合透明质酸钠对膝关节骨性关节炎(KOA)患者疼痛和β-内啡肽、前列腺素E2水平的影响。【方法】选取2019年7月至2021年6月延安市人民医院收治的86例KOA患者,采用随机数字表法将其分为对照组(给予透明质酸钠)和观察组(给予加巴喷丁+透明质酸钠),每组43例。对比两组VAS评分、膝关节功能评分、血清β-内啡肽、前列腺素E_(2)及安全性。【结果】治疗前,两组患者VAS评分、血清β-内啡肽、前列腺素E2水平、膝关节Lysholm评分比较,差异均无统计学意义(P>0.05)。与治疗前相比,治疗1、2、4周后两组患者VAS评分均降低,且治疗2周后、治疗4周后观察组VAS评分均低于对照组(均P<0.001)。治疗后,两组患者血清β-内啡肽水平均升高,前列腺素E2水平则均降低,且观察组β-内啡肽水平高于对照组(P<0.001),前列腺素E2水平则低于对照组(P<0.001)。治疗后,两组患者膝关节Lysholm评分均升高,且观察组膝关节Lysholm评分高于对照组(P<0.001)。两组不良反应总发生率比较,差异无统计学意义(χ^(2)=0.453,P=0.501)。【结论】KOA患者采用加巴喷丁联合透明质酸钠进行治疗可有效缓解疼痛,调节β-内啡肽、前列腺素E_(2)水平,改善膝关节功能,且安全可靠,值得临床推广应用。【Objective】To investigate the effect of gabapentin combined with sodium hyaluronate on pain,β-endorphin and prostaglandin E2 levels in patients with knee osteoarthritis(KOA).【Methods】A total of 86 patients with KOA treated in Yan'an people's Hospital from July 2019 to June 2021 were randomly divided into control group(given sodium hyaluronate)and observation group(given gabapentin+sodium hyaluronate),with 43 cases in each group.VAS score,knee function score and serumβ-Endorphin,prostaglandin E2 and their safety were compared between the two groups.【Results】Before treatment,there was no significant difference in VAS score,serumβ-endorphin,prostaglandin E2 level and knee Lysholm score between the two groups(P>0.05).Compared with before treatment,the VAS scores of the two groups decreased after 1,2 and 4 weeks of treatment,and the VAS scores of the observation group after 2 weeks of treatment and 4 weeks of treatment were lower than those of the control group(P<0.001).After treatment,the levels of the serumβ-endorphins of the two groups of patients increased and the levels of prostaglandin E2 decreased in the observation group;The level ofβ-endorphin was higher than that in the control group(P<0.001),and the level of prostaglandin E2 was lower than that in the control group(P<0.001).After treatment,the knee Lysholm score of the two groups increased,and the knee Lysholm score of the observation group was higher than that of the control group(P<0.001).The total incidence of adverse reactions was similar between the two groups(χ2=0.453,P=0.501).【Conclusion】Gabapentin combined with sodium hyaluronate in the treatment of KOA patients can effectively relieve pain and regulate the levels ofβ-endorphin and prostaglandin E2,and improve knee functions,which is safe and reliable,and is worthy of clinical application.

关 键 词：骨关节炎 膝/药物疗法 透明质酸/治疗应用 乙酸盐类/治疗应用 β内啡肽/血液 地诺前列酮/血液 

分 类 号：R684.3[医药卫生—骨科学]