老年慢性心衰合并铁缺乏患者血清Hep、TRF、SF、Fe水平与左心室结构、血管内皮功能的相关性  

Relationship between the Expression of Serum Hep,TRF,SF,Fe and Left Ventricular Structure and Vascular Endothelial Function in Elderly Patients with Chronic Heart Failure Complicated with Iron Deficiency

作　　者：张亭 任锋 ZHANG Ting;REN Feng(Xi'an International Medical Center Hospital,Xi'an Shaanxi 710000)

机构地区：[1]西安医学国际中心医院,陕西西安710000 [2]武警陕西省总队医院,陕西西安710000

出　　处：《医学临床研究》2022年第4期575-578,共4页Journal of Clinical Research

摘　　要：【目的】探讨老年慢性心衰(CHF)合并铁缺乏患者血清铁调素(Hep)、转铁蛋白(TRF)、铁蛋白(SF)、铁(Fe)水平与左心室结构、血管内皮功能的相关性。【方法】选取2019年1月至2021年1月西安医学国际中心医院收治的92例老年CHF合并铁缺乏患者,根据治疗3个月后是否发生主要心脏主良事件(MACE)将其分为MACE组(n=25)与无MACE组(n=67)。比较两组血清Hep、TRF、SF、Fe水平,左心室结构指标[左心房内径(LAD)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、室间隔厚度(IVST)、左心室质量指数(LVMI)],血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)]。分析血清Hep、TRF、SF、Fe水平与左心室结构、血管内皮功能指标的相关性,评估血清Hep、TRF、SF、Fe水平对MACE的预测价值。【结果】MACE组血清Hep水平高于无MACE组,血清TRF、SF、Fe水平低于无MACE组(P<0.05);血清Hep水平与LAD、LVEDD、LVESD、IVST、LVMI、ET-1呈正相关,与NO呈负相关,血清TRF、SF、Fe水平与LAD、LVEDD、LVESD、IVST、LVMI、ET-1呈负相关,与NO呈正相关(P<0.05)。血清Hep、TRF、SF、Fe联合预测老年CHF并铁缺乏患者发生MACE的曲线下面积(AUC)最大,为0.957。【结论】血清Hep、TRF、SF、Fe水平与老年CHF合并铁缺乏患者左心结构、血管内皮功能具有显著相关性,四者联合检测对预测MACE发生具有重要价值。【Objective】To investigate the correlation between serum ferritin(HEP),transferrin(TRF),ferritin(SF),iron(Fe)and left ventricular structure and vascular endothelial function in elderly patients with chronic heart failure(CHF)complicated with iron deficiency.【Methods】A total of 92 elderly patients with CHF complicated with iron deficiency treated in Xi'an International Medical Center Hospital from January 2019 to January 2021 were divided into MACE group(n=25)and no MACE group(n=67)according to whether MACE occurred after 3 months of treatment.The levels of serum Hep,TRF,SF and Fe,left ventricular structural indexes[left atrial diameter(LAD),left ventricular end diastolic diameter(LVEDd),left ventricular end systolic diameter(LVESD),ventricular septal thickness(IVST),left ventricular mass index(LVMI)]and vascular endothelial function indexes[nitric oxide(NO),endothelin-1(ET-1)]were compared between the two groups.The correlation between serum Hep,TRF,SF and Fe levels and left ventricular structure and vascular endothelial function was analyzed,and the predictive value of serum Hep,TRF,SF and Fe levels to MACE was evaluated.【Results】The levels of serum Hep in the MACE group were higher than those in non MACE group,and the levels of serum TRF,SF and Fe were lower than those in the non MACE group(P<0.05);Serum Hep levels were positively correlated with LAD,LVEDD,LVESD,IVST,LVMI and ET-1 and negatively correlated with No.Serum TRF,SF and Fe levels were negatively correlated with LAD,LVEDd,LVESD,IVST,LVMI and ET-1 and positively correlated with NO(P<0.05).The area under the curve(AUC)of serum Hep,TRF,SF and Fe in predicting MACE in elderly patients with CHF complicated with iron deficiency was the largest,which was 0.957.【Conclusion】The levels of serum Hep,TRF,SF and Fe are significantly correlated with left ventricular structure and vascular endothelial function in elderly patients with CHF complicated with iron deficiency.The combined detection of the four is of great value in predicting the occurrence

关 键 词：心力衰竭/并发症 慢性病 铁/缺乏 铁/代谢 内皮 血管 老年人 

分 类 号：R541.61[医药卫生—心血管疾病]