硫酸镁联合补肾健脾法治疗先兆流产对孕妇雌激素水平和胎儿健康状态的影响  

Effect of magnesium sulfate combined with tonifying kidney and strengthening spleen on estrogen level and fetal health status of pregnant women with threatened abortion

作　　者：赵乐 刘伟 郑义婷[1] ZHAO Le;LIU Wei;ZHENG Yi-ting(Department of Children Health Care,Anhui Wanbei Coal and Electricity Group General Hospital,Suzhou Anhui 234011,China)

机构地区：[1]安徽皖北煤电集团总医院儿童保健科,安徽宿州234011

出　　处：《临床和实验医学杂志》2022年第8期870-874,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省自然基金项目(编号:20198085N)。

摘　　要：目的 观察硫酸镁联合补肾健脾法治疗先兆流产对孕妇雌激素水平和胎儿健康状态的影响。方法 回顾性选取2018年1月至2020年3月安徽皖北煤电集团总医院收治的先兆流产患者110例,根据治疗方法不同分为两组,每组各55例。对照组给予硫酸镁治疗,观察组给予硫酸镁联合补肾健脾法治疗,均连续给药3周。记录两组治疗前后主要症状评分、激素水平[孕酮、雌二醇、β人绒毛膜促性腺激素(β-h CG)]及子宫动脉血流频谱指标的变化,并统计两组临床症状停止时间、保胎成功率、胎儿健康状态及不良反应发生率。结果 两组阴道出血、腰酸胀痛及小腹痛停止时间比较,差异无统计学意义(P> 0.05)。观察组保胎成功率为92.73%,高于对照组(78.18%),差异有统计学意义(P <0.05)。观察组早产率、低体重儿率分别为9.09%、3.64%,低于对照组(25.45%、14.55%),差异有统计学意义(P <0.05)。两组畸形儿率、巨大儿率、围生儿死亡率、不良反应率比较,差异无统计学意义(P> 0.05)。治疗后,两组阴道流血量、流血时间、流血色质及坠胀与下腹部疼痛评分均较治疗前下降,观察组主要症状评分均低于对照组,差异均有统计学意义(P <0.05)。治疗后,两组孕酮、雌二醇、β-HCG水平均较治疗前升高,观察组孕酮、雌二醇、β-HCG水平均高于对照组,差异均有统计学意义(P <0.05)。治疗后,两组阻力系数、搏动系数、收缩期/舒张期比值均较治疗前下降,观察组阻力系数、搏动系数、收缩期/舒张期比值均低于对照组,差异均有统计学意义(P <0.05)。结论 硫酸镁联合补肾健脾法治疗先兆流产可改善患者激素水平,促进症状的消失,提高保胎成功率,减少早产和低体重儿的发生。Objective To observe the effect of magnesium sulfate combined with the method of invigorating the kidney and spleen in the treatment of threatened abortion on the estrogen level of pregnant women and the health of the fetus.Methods A total of 110 patients admitted to Anhui Wanbei Coal and Electricity Group General Hospital from January 2018 to March 2020 were retrospectively divided into two groups and 55 patients in each group.The control group was treated with magnesium sulfate,and the observation group was received magnesium sulfate combined with kidney and spleen method,all continuously for 3 weeks.The changes of main symptom scores,hormone level[progesterone(P),estradiol(E2),βhuman chorionic gonadotropin(β-hCG)]and uterine artery flow spectrum in the two groups were recorded,and the stop time of clinical symptoms,the success rate of fetal preservation,fetal health status and the incidence of adverse reactions were recorded in the two groups were recorded.Results There was no significant difference in the stopping time of vaginal bleeding,lumbar pain and abdominal pain between the two groups(P>0.05).The success rate of pregnancy preservation in the observation group was 92.73%,which was higher than that in the control group(78.18%),the difference was statistically significant(P<0.05).The preterm birth rate and the low birth weight rate in the observation group were 9.09%and 3.64%,respectively,which were lower than those in the control group(25.45%and 14.55%),the difference was statistically significant(P<0.05).There was no significant difference in the rate of deformity,macrosomia,perinatal mortality and adverse reaction rate between the two groups(P>0.05).After treatment,the vaginal bleeding volume,bleeding time,bleeding color quality,swelling and lower abdominal pain scores of the two groups gradually decreased,the main symptom scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of P,E2 andβ-HCG i

关 键 词：硫酸镁 补肾健脾法 先兆流产 激素 子宫动脉血流 保胎 

分 类 号：R714.21[医药卫生—妇产科学]