拉萨地区1196例藏族儿童维生素D营养状态分析  

A survey of vitamin D nutritional status in 1196 Tibetan children in Lhasa

作　　者：尼玛顿珠[1] 秦绪珍[2] 边珍[1] 张婉[3] NIMA Dunzhu;QIN Xuzhen;BIAN Zhen;ZHANG Wan(Department of Clinical Laboratory,the People′s Hospital of Tibet Autonomous Region,Lhasa,Tibet 850000,China;Department of Clinical Laboratory,Peking Union Medical College Hospital,Beijing 100730,China;Department of Pediatrics,the People′s Hospital of Tibet Autonomous Region,Lhasa,Tibet 850000,China)

机构地区：[1]西藏自治区人民医院检验科,西藏拉萨850000 [2]中国医学科学院北京协和医院检验科,北京100730 [3]西藏自治区人民医院儿科,西藏拉萨850000

出　　处：《检验医学与临床》2022年第10期1337-1339,1343,共4页Laboratory Medicine and Clinic

基　　金：中国医学科学院中央级公益性科研院所资助项目(2020-RW330-004)。

摘　　要：目的 分析拉萨地区0~12岁儿童血清维生素D水平分布,观察地域、性别、年龄、季节对儿童维生素D营养状态的影响。方法 纳入在西藏自治区人民医院门诊就诊的1 196例0~12岁儿童,排除明确诊断患儿,采用索霖化学发光法检测血清25(OH)D水平,收集性别、年龄、检测日期等相关信息,并进行统计分析。结果 拉萨地区0~12岁儿童血清25(OH)D总体水平为19.7(10.2,27.9)ng/mL。1 196例儿童中维生素D严重缺乏、缺乏、不足、充足、过量组患儿分别占24.3%、26.9%、27.2%、21.3%、0.3%。不同年龄、性别25(OH)D水平比较,差异有统计学意义(P<0.05),男童高于女童(P<0.05),学龄前儿童25(OH)D水平最高。夏、秋季儿童25(OH)D水平高于春季,春季高于冬季,冬季维生素D缺乏、不足率明显高于其他3季,差异有统计学意义(P<0.05)。结论 拉萨市0~12岁儿童普遍存在维生素D缺乏,应补充维生素D含量较高食物的摄入,加强户外运动。Objective To investigate the distribution of serum vitamin D levels in children aged 0-12 years in Lhasa,and to analyze the influence of region,gender,age and season on the on children′s vitamin D nutritional status in this region.Methods A total of 1 196 children aged 0-12 years from the outpatient department of the People′s Hospital of Tibet Autonomous Region were included in this study.Children with a definitive diagnosis were excluded.The serum 25(OH)D level was determined by soluminescence chemiluminescence method,and the information of gender,age and detection date were collected and analyzed statistically.Results The average level of serum 25(OH)D was 19.7(10.2,27.9) ng/mL in children aged 0-12 years.Among the 1 196 children,24.3%,26.9%,27.2%,21.3%,and 0.3% were in the groups of severe vitamin D deficiency,deficiency,insufficiency,sufficient,and excess respectively.There were statistically significances in 25(OH)D among different ages and genders(P<0.05).The average level of 25(OH)D in the boys was higher than that in girls(P<0.05),and the highest level of 25(OH)D was found in preschool children.The average concentration of 25(OH)D in summer and autumn was higher than that in spring,and the 25(OH)D level in spring was higher than that in winter.In winter,the ratio of vitamin D deficiency and insufficiency were significantly higher than those of the other three seasons(P<0.05).Conclusion Vitamin D deficiency is common in children aged 0-12 years in Lhasa,therefore,food intake with higher vitamin D content should be supplemented and outdoor exercise should be strengthened.

关 键 词：儿童 维生素D缺乏 25-羟维生素D 拉萨 

分 类 号：R153.2[医药卫生—营养与食品卫生学]