不同剂量、不同给药方式的纳洛酮对急性重型脑伤患者脑功能的影响  

Effects of Naloxone with Different Doses and Administration Methods on Brain Function in Patients with Acute Severe Brain Injury

作　　者：王新厂[1] 郭电渠[1] 韩冰[1] WANG Xinchang;GUO Dianqu;HAN Bing(Department of Neurosurgery,Zhengzhou First People’s Hospital,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州市第一人民医院神经外科,河南郑州450000

出　　处：《中国药物滥用防治杂志》2022年第3期304-307,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20200703)。

摘　　要：目的:探讨不同剂量、不同给药方式的纳洛酮对急性重型脑伤患者脑功能的影响。方法:选择2019年2月—2021年2月在该院治疗的120例急性重型脑伤患者,根据随机数字表法分为4组,各30例。甲、乙两组采用静脉注射给药的方式,给药的剂量分别为2 mg、4 mg;丙、丁两组采用持续静脉滴注给药的方式,给药的剂量分别为4.8 mg/d、0.3 mg/(kg·d),比较4组用药前后总功率变化情况。结果:甲、乙两组T_(1)、T_(2)时总功率比较,差异有统计学意义(P<0.05);其他阶段总功率比较,差异无统计学意义(P>0.05)。丙、丁两组T_(2)~T_(4)时总功率比较,差异有统计学意义(P<0.05);其他阶段总功率比较,差异无统计学意义(P>0.05)。结论:纳洛酮在用药初期采用4 mg静脉注射给药,用药后期采用0.3 mg/(kg·d)持续静脉滴注给药效果较好。Objective:To investigate the effects of naloxone with different doses and administration methods on brain function in patients with acute severe brain injury.Methods:A total of 120 patients with acute severe brain injury treated in our hospital from February 2019 to February 2021 were selected and divided into 4 groups accciding to the random table,with 30 cases in each group.Group A and group B were given intravenous injection of 2 mg and 4 mg,respectively.Group C and group D were given continuous intravenous drip,and the doses were 4.8 mg/d and 0.3 mg/(kg·d),respectively.The changes of total power before and after treatment in the four groups were compared.Results:There was statistically significant difference in total power between group A and group B at T_(1) and T_(2)(P<0.05),there was no statistically significant difference in the total power between the two groups at other stages(P>0.05).There was statistically significant difference in total power between group C and group D at T_(2)-T_(4)(P<0.05),there was no statistically significant difference in the total power between the two groups at other stages(P>0.05).Conclusion:Naloxone was administered by 4 mg intravenous injection at the early stage of medication,and 0.3 mg/(kg·d)continuous intravenous infusion at the late stage of medication is effective.

关 键 词：不同剂量 不同给药方式 纳洛酮 急性重型脑伤 脑功能 

分 类 号：R651.15[医药卫生—外科学]