HMGB1/TLR4通路在患反复支气管肺炎的老年患者治疗中的作用  

Role of HMGB1/TLR4 pathway in the treatment of elderly patients with recurrent bronchopneumonia

作　　者：宋威 万健[1] 白金霞 韩振[1] 梁宇平 孙杰[1] 陈嵩[1] 卢昕媛 SONG Wei;WAN Jian;BAI Jin-xia(Department of Emergency and Critical Care Medicine,Pudong New Area People's Hospital,Shanghai 201299,China)

机构地区：[1]上海市浦东新区人民医院急诊与重症医学科,上海201299

出　　处：《临床和实验医学杂志》2022年第7期712-715,共4页Journal of Clinical and Experimental Medicine

基　　金：上海市浦东新区卫生系统领先人才培养计划(编号:PWRl2018-08)。

摘　　要：目的分析高迁移率族蛋白-1(HMGB1)/Toll样受体4(TLR4)通路表达反复支气管肺炎患者治疗中的作用。方法回顾性选取2020年1月至2021年9月上海市浦东新区人民医院收治的反复支气管肺炎患者作为研究组(n=50),普通肺炎患者作为普通组(n=50),同期健康体检者作为对照组(n=50)。比较3组对象的HMGB1/TLR4、炎症因子[白细胞介素(IL)-6、IL-8、肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)]水平,并比较研究组不同病原体感染类型人群HMGB1/TLR4水平。结果研究组外周血HMGB1/TLR4水平分别为(99.13±20.37)、(45.93±12.44)ng/mL,高于普通组[(66.43±11.61)、(26.77±9.35)ng/mL]和对照组[(50.75±10.34)、(17.20±6.64)ng/mL],普通组外周血HMGB1/TLR4水平也高于对照组,差异均有统计学意义(P<0.05)。≥2种病原体感染者外周血HMGB1/TLR4水平分别为(108.96±23.45)、(48.93±13.51)ng/mL,高于单一病原体感染者[(88.91±19.31)、(31.07±9.46)ng/mL],差异均有统计学意义(P<0.05)。研究组外周血IL-6、IL-8、TNF-α、hs-CRP水平分别为(56.88±9.41)、(66.78±10.32)、(53.66±7.49)、(57.39±6.12)pg/mL,均高于普通组[(43.22±7.63)、(54.52±9.68)、(41.99±8.69)、(39.34±6.41)pg/mL]和对照组[(18.91±8.25)、(21.71±6.54)、(25.81±6.13)、(16.57±5.14)pg/mL],普通组外周血IL-6、IL-8、TNF-α、hs-CRP水平分别高于对照组,差异均有统计学意义(P<0.05)。结论HMGB1及其介导TLR4信号通路在反复支气管肺炎患者中呈现高表达,干扰抑制HMGB1表达可下调TLR4通路表达,对阻滞病毒诱导支气管上皮细胞分泌炎症因子有重要作用。Objective To analyze the role of high mobility group protein-1(HMGB1)/Toll-like receptor 4(TLR4)pathway expression in the treatment of patients with recurrent bronchopneumonia.Methods Patients with recurrent bronchopneumonia admitted to Pudong New Area People's Hospital from January 2020 to September 2021 were retrospectively selected as the study group(n=50),patients with common pneumonia as the general group(n=50),and healthy subjects during the same period as the control group(n=50).The levels of HMGB1/TLR4,inflammatory factors[interleukin(IL)-6,IL-8,tumor necrosis factor alpha(TNF-α),high-sensitivity C-reactive protein(hs-CRP)]in the three groups were compared,and the levels of HMGB1/TLR4 in different pathogen infection types of the study group were compared.Results The levels of HMGB1/TLR4 in peripheral blood of the study group were(99.13±20.37)ng/mL,(45.93±12.44)ng/mL respectively,which were higher than those of the normal group[(66.43±11.61)ng/mL,(26.77±9.35)ng/mL]and the control group[(50.75±10.34)ng/mL,(17.20±6.64)ng/mL],and the levels of HMGB1/TLR4 in peripheral blood of the normal group were also higher than those of the control group,the differences were statistically significant(P<0.05).The levels of HMGB1/TLR4 in peripheral blood of patients infected with≥2 pathogens were(108.96±23.45)ng/mL,(48.93±13.51)ng/mL respectively,which were higher than those of patients infected with single pathogen[(88.91±19.31)ng/mL,(31.07±9.46)ng/mL],the differences were statistically significant(P<0.05).The levels of IL-6,IL-8,TNF-αand hs-CRP in peripheral blood of the study group were(56.88±9.41)pg/mL,(66.78±10.32)pg/mL,(53.66±7.49)pg/mL,(57.39±6.12)pg/mL respectively,which were high than those of the normal group[(43.22±7.63)pg/mL,(54.52±9.68)pg/mL,(41.99±8.69)pg/mL,(39.34±6.41)pg/mL]and the control group[(18.91±8.25)pg/mL,(21.71±6.54)pg/mL,(25.81±6.13)pg/mL,(16.57±5.14)pg/mL],the levels of IL-6,IL-8,TNF-αand hs-CRP in peripheral blood of the normal group were higher than those of the contro

关 键 词：反复支气管肺炎 高迁移率族蛋白-1 TOLL样受体4 信号通路 作用机制 

分 类 号：R563.12[医药卫生—呼吸系统]