皮秒激光联合酶面膜治疗黄褐斑的临床疗效分析  

Clinical efficacy analysis of picosecond laser combined with enzyme mask in the treatment of melasma

作　　者：郑佳兴 陈沫君 杨高云[1] ZHENG Jia-xing;CHEN Mo-jun;YANG Gao-yun(Department of Dermatology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院皮肤科,北京100050

出　　处：《临床和实验医学杂志》2022年第7期744-748,共5页Journal of Clinical and Experimental Medicine

基　　金：北京市卫生系统高层次卫生技术人才培养基金(编号:2013-2-025)。

摘　　要：目的探索皮秒激光联合酶面膜对黄褐斑治疗的有效性和安全性。方法前瞻性选取首都医科大学附属北京友谊医院门诊招募的40例黄褐斑患者作为研究对象进行研究,将患者按照1∶1原则随机分为试验组和对照组各20例。试验组为皮秒激光联合酶面膜治疗,每4周进行一次皮秒激光治疗,共治疗3次,酶面膜治疗每2周1次,共治疗6次。对照组皮秒激光治疗同前,术后医用保湿面膜外敷,末次治疗后1月进行随访。对两组治疗前后的改良黄褐斑面积和严重指数(mMASI)评分、医生整体评价(PGA)评分、患者满意度、黄褐斑生活质量指数量表(MelasQoL)评分及相关评分组间改善率进行统计学分析,并记录相关不良反应。结果试验组随访时mMASI评分为[2.80(1.88,3.83)]分,较治疗前[(5.28±1.74)分]下降,对照组随访时mMASI评分为[3.00(2.70,4.35)]分,评分较治疗前[(5.34±1.55)分]下降,差异均有统计学意义(P<0.05);试验组改善率为(42.01±16.64)%,优于对照组[(32.95±10.64)%],差异有统计学意义(P<0.05)。两组间PGA评分差异无统计学意义(P>0.05)。试验组满意度方面试验组优于对照组,差异有统计学意义(P<0.05)。试验组随访时MelasQoL评分为[19.50(15.25,34.75)]分,较治疗前[(36.75±15.20)分]下降,对照组随访时MelasQoL评分为(29.10±11.34)分,较治疗前[(34.85±12.88)分]下降,差异均有统计学意义(P<0.05);随访时试验组MelasQoL评分改善率为33.33%,优于对照组(15.34%),差异有统计学意义(P<0.05)。治疗中均未发现严重不良反应。结论皮秒激光联合酶面膜对黄褐斑的治疗有效率及满意度高,安全性好,对于MelasQoL评分及mMASI评分改善情况尚佳,可以成为临床中黄褐斑的治疗选择之一。Objective To analyze the efficiency and safety of picosecond laser combined with enzyme mask in the treatment of melasma.Methods Forty melasma patients recruited from outpatient clinic of Beijing Friendship Hospital,Capital Medical University were prospectively selected for the randomized controlled study,and according to the principle of 1∶1,the patients were randomly divided into the experimental group and the control group with 20 cases in each.The test group was treated with picosecond laser combined with enzyme mask,with picosecond laser treatment every four weeks for a total of three treatments and enzyme mask treatment every two weeks for a total of six treatments.The control group was treated with the same picosecond laser as before,with a postoperative medical moisturising mask applied and followed up 1 month after the last treatment.The improved melasma area and severity index(mMASI)scores,physician global assessment(PGA)scores,satisfaction,melasma quality of life index scale(MelasQoL)scores and related scores were analyzed between groups before and after treatment in both groups.And related adverse reactions were recorded.Results The mMASI scores of the experimental group at follow-up were[2.80(1.88,3.83)]points,which were lower than those before treatment[(5.28±1.74)points],the mMASI scores of the control group at follow-up were[3.00(2.70,4.35)]points,which were lower than those before treatment[(5.34±1.55)points],the differences were statistically significant(P<0.05).The improvement rate of mMASI score the experimental group was(42.01±16.64)%,which was better than that of the control group[(32.95±10.64)%],and the difference was statistically significant(P<0.05).There was no significant difference in PGA score between the two groups(P>0.05).The experimental group was better than the control group in terms of satisfaction,and the difference was statistically significant(P<0.05).The MelasQoL scores in the experimental group were[19.50(15.25,34.75)]points,which were lower than those before treatmen

关 键 词：黄褐斑 皮秒激光 酶面膜 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]