肺NK细胞及其在肺部疾病中作用的研究进展  

Research progress of lung natural killer cells and their roles in pulmonary diseases

作　　者：袁玉 彭璐 陈采陶 史阳琳 徐玉东 王宇[1] 杨永清 陈艳焦 YUAN Yu;PENG Lu;CHEN Caitao;SHI Yanglin;XU Yudong;WANG Yu;YANG Yongqing;CHEN Yanjiao(Laboratory of Molecular Biology of Acupuncture,Shanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院上海市针灸经络研究所分子生物学(针灸)实验室,上海200030

出　　处：《细胞与分子免疫学杂志》2022年第2期183-190,共8页Chinese Journal of Cellular and Molecular Immunology

基　　金：上海市青年英才扬帆计划项目(20YF1445300);上海市卫生健康委员会科研项目(20194Y0164);国家自然科学基金(81973951,81973952);国家重点研发计划(2018YFC1704600)。

摘　　要：肺自然杀伤(NK)细胞可分为组织驻留NK(trNK)细胞与传统NK(cNK)细胞两类,它们均由多种具有独特表型和功能特征的子集组成,但是二者在表型和功能方面的较大差异尚未引起重视。我们总结了trNK与cNK细胞的发育、表型和功能特点,介绍了肺NK细胞与其他免疫细胞的相互作用关系,并重点论述了肺NK细胞在肺部感染、肿瘤、肺移植、哮喘及其他疾病中的最新研究进展。研究结果提示尽管肺NK细胞是以cNK为主,但trNK细胞可能起着关键作用。对肺trNK和cNK细胞特征之间的研究,将为基于NK细胞的疾病研究提供新的思路。Lung natural killer(NK)cells can be classified into tissue-resident NK(trNK)cells and conventional NK(cNK)cells.Both trNK and cNK are composed of multiple subsets with unique phe no types and functional characteristics.However,the phenotypic and functional differences between the two captured less attention.The features of trNK and cNK in the developme nt,phe no types and functi ons are sorted,and the in teractions between NK cells and other immune cells in the lung are presented.Moreover,the latest research progress of lung NK cells in lung infections,tumors,transplantation,asthma and other diseases is particularly highlighted.It suggests that trNK cells may play a significant role,although lung NK cells are mainly composed of cNK.Further in vestigati ons of lung trNK and cNK cells will provide new in sights into NK cell-based disease research.

关 键 词：自然杀伤(NK)细胞 分化发育 细胞分类 细胞功能 肺部疾病 综述 

分 类 号：R392.11[医药卫生—免疫学] R392.12[医药卫生—基础医学]