疼痛方外敷联合散膝汤对膝关节慢性滑膜炎患者白细胞介素1β、基质金属蛋白酶-3、5-羟色胺、肿瘤坏死因子-α水平的影响  被引量:5

Discussion on Sweating after ThEffect of External Application of Pain Recipe and Sanxi Decoction on IL-1β,MMP-3,5-HT and TNF-αLevels in Patients with Knee Joint Chronic Synovitis

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作  者:李雪梅 于继岗 LI Xue-mei;YU Ji-gang(Chengdu First Orthopaedic Hospital,Chengdu Sichuan 610091;Baoji Traditional Chinese Medicine Hospital of Shaanxi Province,Baoji Shaanxi 721000)

机构地区:[1]成都第一骨科医院,四川成都610091 [2]陕西省宝鸡市中医医院,陕西宝鸡721000

出  处:《世界中西医结合杂志》2022年第2期359-363,共5页World Journal of Integrated Traditional and Western Medicine

基  金:四川省卫生和计划生育委员会课题(20190014)。

摘  要:目的探讨疼痛方外敷联合散膝汤对膝关节慢性滑膜炎患者白细胞介素1β(Interleukin-1β,IL-1β)、基质金属蛋白酶-3(Matrix metalloproteinase-3,MMP-3)、5-羟色胺(5-hydroxytryptamine,5-HF)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)水平的影响。方法选取2020年1月—2021年1月期间成都第一骨科医院诊治的膝关节慢性滑膜炎患者112例,采用随机数字表法分为对照组和研究组,每组各56例。其中对照组给予散膝汤治疗,研究组给予疼痛方外敷联合散膝汤治疗。治疗1个月后,观察比较两组患者中医证候积分、肿胀程度、疼痛程度、膝关节功能评分、IL-1β、MMP-3、5-HT、TNF-α水平及临床疗效。结果治疗后两组患者膝关节酸痛重着、膝关节活动受限、肌肉硬实、肢体沉重、遇寒加重、肿胀程度、疼痛程度、膝关节功能、IL-1β、MMP-3、5-HT、TNF-α水平均较治疗前改善,差异有统计学意义(P<0.05);且研究组治疗后临床疗效、膝关节酸痛重着、膝关节活动受限、肌肉硬实、肢体沉重、遇寒加重、肿胀程度、疼痛程度、膝关节功能、IL-1β、MMP-3、5-HT、TNF-α水平均优于对照组,差异有统计学意义(P<0.05)。结论膝关节慢性滑膜炎采用疼痛方外敷联合散膝汤治疗能够有效降低IL-1β、MMP-3、5-HT、TNF-α水平,降低炎症及疼痛因子水平。Objective To investigate the effects of external application of Pain Recipe combined with Sanxi Decoction on the levels of interleukin-1β(IL-1β),matrix metalloproteinase-3(MMP-3),5-hydroxytryptamine(5-HF)and tumor necrosis factor-α(TNF-α)levels in patients with chronic synovitis of the knee joint.Methods A total of 112 patients with chronic synovitis of knee joint diagnosed and treated in Chengdu First Orthopaedic Hospital from January 2020 to January 2021 were selected and divided into control group and study group by random number table method,with 56 cases in each group.The control group was given Sanxi Decoction,and the research group was given external application of Pain Recipe combined with Sanxi Decoction.After 1 month of treatment,the scores of TCM syndromes,swelling,pain degree,knee joint function scores,IL-1β,MMP-3,5-HT and TNF-αlevels were compared between the two groups before and after treatment to observe the clinical efficacy.Results After treatment,the two groups of patients had severe knee joint pain,limited knee joint movement,firm muscles,heavy limbs,aggravated cold,swelling degree,pain degree,knee joint function,IL-1β,MMP-3,5-HT,and TNF-αwere improved compared with those before treatment,and the difference was statistically significant(P<0.05).After treatment,the clinical efficacy,severe knee pain,limited knee movement,firm muscles,heavy limbs,and aggravation of cold in the study group,swelling degree,pain degree,knee joint function,IL-1β,MMP-3,5-HT,TNF-αlevels were better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of chronic synovitis of the knee joint with external applicationof Pain Recipe combined with Sanxi Decoction can effectively reduce the levels of IL-1β,MMP-3,5-HT and TNF-α,and reduce the levels of inflammation and pain factors.

关 键 词:膝关节慢性滑膜炎 疼痛方外敷 散膝汤 白细胞介素1Β 基质金属蛋白酶-3 5-羟色胺 肿瘤坏死因子-Α 

分 类 号:R684.3[医药卫生—骨科学]

 

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