地藤痹痛颗粒配合针刺治疗类风湿关节炎的疗效观察  

Effect of Diteng Bitong Granule and Acupuncture on Rheumatoid Arthritis

作　　者：黎丽 卢宣娇 蔡贤华[2] LI Li;LU Xuan-jiao;CAI Xian-hua(Department of Joint Surgery,Enshi Central Hospital,Enshi Hubei 445000;Department of Orthopedics,Wuhan General Hospital of Guangzhou Military Command,Wuhan Hubei 430070)

机构地区：[1]湖北省恩施州中心医院关节外科,湖北恩施445000 [2]广州军区武汉总医院骨科,湖北武汉430070

出　　处：《世界中西医结合杂志》2022年第2期380-383,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：2015—2016年度省卫生计生委科研立项项目(WJ2015MA013)。

摘　　要：目的探讨地藤痹痛颗粒配合针刺治疗类风湿关节炎(Rheumatoid arthritis,RA)的疗效。方法选取2018年6月—2020年6月期间湖北省恩施州中心医院收治的RA患者86例,按随机数字表法分为对照组和治疗组,每组各43例。对照组采用常规西医治疗,治疗组在对照组基础上采用地藤痹痛颗粒配合针刺治疗。治疗后对两组患者的临床疗效、症状积分、疾病活动度(DAS28评分)、实验室指标[C-反应蛋白(C-reactive protein,CRP)、抗环瓜氨酸肽(cyclic citrullinated peptide,CCP)抗体、血沉(Erythrocyte sedimentation Rate,ESR)、类风湿因子(Rheumatoid factor,RF)]进行分析和比较。结果观察组患者总缓解率为90.70%(39/43)明显高于对照组74.42%(32/43),差异有统计学意义(P<0.05)。治疗后两组患者症状积分较治疗前明显降低,差异有统计学意义(P<0.05);且观察组患者症状积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组患者DAS28评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者CRP、抗CCP抗体、RF、ESR水平均较治疗前明面降低,差异有统计学意义(P<0.05);且观察组患者的CRP、抗CCP抗体、RF、ESR水平明显低于对照组,差异有统计学意义(P<0.05)。结论地藤痹痛颗粒联合针刺治疗RA能明显改善患者的肿胀、晨僵、疼痛的临床症状,改善疾病活动度,其机制可能与降低C-反应蛋白、抗环瓜氨酸肽抗体、血沉、类风湿因子水平有关。Objective To investigate the efficacy of Diteng Bitong Granules combined with acupuncture in the treatment of rheumatoid arthritis(RA).Methods A total of 86 RA patients admitted to Enshi Central Hospital in Hubei Province from June 2018 to June 2020 were selected and divided into a control group and a treatment group according to the random number table method,with 43 cases in each group.The control group was treated with conventional western medicine,while the treatment group was treated with Diteng Bitong Granules combined with acupuncture on the basis of the control group.After treatment,the clinical efficacy,TCM syndrome and symptom score,disease activity(DAS28 score),laboratory indicators[C-reactive protein(CRP),anti-cyclic citrullinated peptide antibody(cyclic citrullinated peptide)citrullinated peptide antibody(CCP),Erythrocyte sedimentation Rate(ESR),and rheumatoid factor(RF)]were analyzed and compared.Results The total remission rate of the observation group was 90.70%(39/43),which was significantly higher than that of the control group,74.42%(32/43),with a statistically significant difference(P<0.05).After treatment,the TCM syndrome symptom scores of the two groups of patients were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,the DAS28 score of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CRP,anti-CCP antibody,RF and ESR in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).ESR level was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion The curative effect of Diteng Bitong granule combined with acupuncture on RA is remarkable,which can obviously improve the clinical symptoms of swelling,morning stiffness and pain,and improve the disease activity,which may be related to the decrease of CRP,anti-CCP

关 键 词：地藤痹痛颗粒 针刺 类风湿关节炎 

分 类 号：R593.33[医药卫生—内科学]