疏风宣肺通窍汤联合地塞米松鼓室注射治疗风热外袭型急性分泌性中耳炎的临床观察  

Clinical Observation of Shufeng Xuanfei Tongqiao Decoction Combined with Dexamethasone Tympanic Injection in the Treatment of Acute Secretory Otitis Media with External Attack of Wind-Heat

作　　者：姜锐[1] 彭福梅 彭凌艳[1] 易新林[1] JIANG Rui;PENG Fu-mei;PENG Ling-yan;YI Xin-lin(Hubei Hospital of Traditional Chinese Medicine,Wuhan Hubei 430061;Wuhan Third Hospital,Wuhan Hubei 430061)

机构地区：[1]湖北省中医院,湖北武汉430061 [2]武汉市第三医院,湖北武汉430061

出　　处：《世界中西医结合杂志》2022年第2期394-397,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：湖北自然科学基金委员会医学科学项目(KJ2019A0252)。

摘　　要：目的观察疏风宣肺通窍汤联合地塞米松鼓室注射治疗急性分泌性中耳炎的临床疗效。方法选取2019年9月—2020年9月期间湖北省中医院收治的风热外袭型急性分泌性中耳炎患者82例,采用随机数字表法分为对照组和观察组,每组各41例。两组均给予基础治疗,对照组加用地塞米松鼓室内注射,观察组在对照组基础上给予疏风宣肺通窍汤。两组患者均治疗2周后,观察比较两组患者临床疗效,治疗前后气导纯音听阈均值、症状积分、炎性因子变化及治疗期间不良反应发生情况。结果观察组总有效率92.68%(38/41)明显高于对照组总有效率75.61%(31/41),差异有统计学意义(P<0.05)。治疗后两组患者气导纯音听阈均值及症状积分较治疗前均有下降,差异有统计学意义(P<0.05);且观察组治疗后气导纯音听阈均值及症状积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清IL-2、TNF-α、IL-6水平均明显低于治疗前,差异有统计学意义(P<0.05);且观察组血清IL-2、TNF-α、IL-6水平明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均未出现严重不良反应,观察组不良反应发生率7.32%(3/41)与对照组不良反应发生率4.88%(2/41)比较,差异无统计学意义(P>0.05)。结论疏风宣肺通窍汤联合地塞米松鼓室注射治疗风热外袭型急性分泌性中耳炎,能有效改善症状,降低炎性因子水平,且具有较高安全性。Objective To investigate the clinical value of Shufeng Xuanfei Tongqiao Decoction combined with dexamethasone tympanic injection in the treatment of acute secretory otitis media.Methods A total of 82 patients with acute secretory otitis media of wind-heat extrinsic type who were admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from September 2019 to September 2020 were selected and divided into control group and observation group by random number table method,with 41 cases in each group.Both groups were given basic treatment,the control group was additionally given intratympanic injection of dexamethasone,and the observation group was given Shufeng Xuanfei Tongqiao Decoction on the basis of the control group.After 2 weeks of treatment,the two groups of patients were observed and compared in terms of clinical efficacy,mean air conduction pure tone hearing threshold,symptom scores,changes in inflammatory factors and the occurrence of adverse reactions during treatment before and after treatment.Results The total effective rate of the observation group was 92.68%(38/41),which was significantly higher than that of the control group,which was 75.61%(31/41),and the difference was statistically significant(P<0.05).After treatment,the mean air conduction pure tone hearing threshold and symptom score of the two groups were decreased compared with those before treatment,and the difference was statistically significant(P<0.05).The difference was statistically significant(P<0.05).After treatment,the levels of serum IL-2,TNF-αand IL-6 in the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).The level of 6 was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).During the treatment,no serious adverse reactions occurred in the two groups,and the incidence of adverse reactions in the observation group was 7.32%(3/41)compared with 4.88%(2/41)in the control group,and the difference wa

关 键 词：急性分泌性中耳炎 风热外袭 地塞米松 疏风宣肺通窍汤 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]