自拟益气活血方口服联合温阳散湿方熏洗治疗糖尿病下肢血管病变的临床疗效  

Effect of Oral Administration of Self-Made Yiqi Huoxue Recipe Combined with with Wenyang Sanshi Recipe for Fumigating and Washing in the Treatment of Diabetic Lower Extremity Vascular Disease

作　　者：李家丽 贾学昭 王茎[2] LI Jia-li;JIA Xue-zhao;WANG Jing(The First Affiliated Hospital of Anhui Medical University,Hefei Anhui 230000;Anhui University of Traditional Chi-nese Medicine,Hefei Anhui 230000)

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230000 [2]安徽中医药大学,安徽合肥230000

出　　处：《世界中西医结合杂志》2022年第2期402-406,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：安徽省自然科学基金面上项目(1608085MH230)。

摘　　要：目的探讨自拟益气活血方口服联合温阳散湿方熏洗治疗糖尿病下肢血管病变(Lower extremity arterialdisease in diabetic patients,LEADDP)的临床疗效。方法选取2018年1月—2019年8月期间安徽医科大学第一附属医院收治的120例LEADDP患者,按随机数字表法分为观察组与对照组,每组各60例。对照组采用常规西医治疗,观察组在对照组基础上接受自拟益气活血方口服联合温阳散湿方熏洗治疗。治疗8周后,观察比较两组患者治疗前后中医证候评分、踝肱指数(Ankle brachial index,ABI)、血糖[空腹血糖(Fasting plasma glucose,FPG)、餐后2 h血糖(2 h Postprandial blood glucose,2 h PG)、糖化血红蛋白(Haemoglobin A1c,HbA1c)]、血脂[总胆固醇(Total cholesterol,TC)、血清三酰甘油(Triglyceride,TG)、低密度脂蛋白-胆固醇(Low density lipoprotein-cholesterol,LDL-C)、高密度脂蛋白-胆固醇(High density lipoprotein-choesterol,HDL-C)]及血液流变学(全血黏度高切、全血黏度低切、血浆黏度、红细胞压积)指标及不良反应情况。结果治疗后两组患者中医证候评分明显下降,ABI指标明显上升,差异有统计学意义(P<0.05);且观察组中医证候评分明显低于对照组,ABI指标明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血糖FBG、2 h BG、HbA1c指标与治疗前比较,差异无统计学意义(P>0.05);且两组间比较,差异无统计学意义(P>0.05)。治疗后两组患者血脂TC、TG、LDL-C指标均较治疗前明显下降,HDL-C较治疗前上升,差异有统计学意义(P<0.05);且观察组TC、TG、LDL-C明显低于对照组,HDL-C明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者全血黏度高切、全血黏度低切、血浆黏度、红细胞压积均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组全血黏度高切、全血黏度低切、血浆黏度、红细胞压积均较对照组明显降低,差异有统计学意义(P<0.05)。治疗期间,�Objective To explore the clinical efficacy of self-made Yiqi Huoxue Recipe orally combined with Wenyang Sanshi Recipe for fumigation and washing in the treatment of lower extremity arterial disease in diabetic patients(LEADDP).Methods A total of 120 LEADDP patients admitted to the First Affiliated Hospital of Anhui Medical University from January 2018 to August 2019 were selected and divided into an observation group and a control group according to the random number table method,with 60 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with the self-made Yiqi Huoxue Decoction orally combined with Wenyang Sanshi Decoction fumigation and washing on the basis of the control group.After 8 weeks of treatment,the TCM syndrome score,Ankle brachial index(ABI),blood glucose(Fasting plasma glucose(FPG),2 h postprandial blood glucose(2 hpostprandial blood glucose,FPG)and 2 h postprandial blood glucose(2 h postprandial blood glucose,FPG)were observed and compared in the two groups before and after treatment.2 h PG),glycosylated hemoglobin(Haemoglobin A1 c,HbA1 c),blood lipids[total cholesterol(Totalcholesterol,TC),serum triglyceride(Triglyceride,TG),low density lipoprotein-cholesterol(Lowdensitylipoprotein-cholesterol,LDL-C),High density lipoprotein-cholesterol(High density lipoprotein-choesterol,HDL-C)]and hemorheology(whole blood viscosity high shear,whole blood viscosity low shear,plasma viscosity,hematocrit)indicators and adverse reactions was statistically analyzed.Results After treatment,the scores of TCM syndromes in the two groups were significantly decreased,and the ABI indexes were significantly increased,and the difference was statistically significant(P<0.05).There was no significant difference in blood glucose FBG,2 h BG and HbA1 c between the two groups after treatment(P>0.05),and there was no significant difference between the two groups(P>0.05).After treatment,blood lipid TC,TG and LDL-C indexes in the two groups were significantly decr

关 键 词：糖尿病下肢血管病变 益气活血方 温阳散湿方熏洗 

分 类 号：R587.2[医药卫生—内分泌]