Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles  

作　　者：Yu-Shen Zhu Linlin Shi Lianrong Fu Xiran Chen Xinju Zhu Xin-Qi Hao Mao-Ping Song 

机构地区：[1]College of Chemistry,Zhengzhou University,Zhengzhou 450001,China

出　　处：《Chinese Chemical Letters》2022年第3期1497-1500,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China (Nos. 21672192, 21803059, and U1904212)。

摘　　要：A facile and sustainable approach for the amination of benzothiazoles with KSe CN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles.

关 键 词：Iodine-catalyzed BENZOTHIAZOLES KSeCN WATER Primary 2-benzothiazolamines 

分 类 号：O626.25[理学—有机化学]