[4+1]Cyclization of benzohydrazide and ClCF_(2)COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d_(5)  

作　　者：Ya Wang Shiqiang Mu Xin Li Qiuling Song 

机构地区：[1]Institute of Next Generation Matter Transformation,College of Materials Science&Engineering and College of Chemical Engineering at Huaqiao University,Xiamen 361021,China [2]Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen 518055,China [3]State Key Laboratory of Organometallic Chemistry and Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2022年第3期1511-1514,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(Nos.21772046,2193103);the Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002);Subsidized Project for Cultivating Postgraduates’Innovative Ability in Scientific Research of Huaqiao University。

摘　　要：A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d_(5) via[4+1]cyclization of ClCF_(2)COONa with non-amine compounds containing amino groups is developed.Of note,this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds.The current protocol features simple operation,readily accessible raw materials,wide substrate scope and valuable products.

关 键 词：Transition-metal-free catalyzed [4+1]Cyclization Halofluorinated compounds 1 3 4-Oxadiazoles 

分 类 号：O626[理学—有机化学]