Metal-phenolic networks modified polyurethane as periosteum for bone regeneration  

作　　者：Qingyi Zhang Kai Huang Jie Tan Xiongxin Lei Liping Huang Yuting Song Qianjin Li Chenyu Zou Huiqi Xie 

机构地区：[1]Laboratory of Stem Cell and Tissue Engineering,Orthopedic Research Institute,Med-X Center for Materials,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2022年第3期1623-1626,共4页中国化学快报（英文版）

基　　金：supported by the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University (No.ZYJC18002)。

摘　　要：Treatment of bone defects still poses a great challenge in orthopedic clinics, and the vital role of periosteum in such processes has attracted widespread attention. However, studies focusing on the oxidative stress micro-environment with an artificial periosteum at the site of defect have been scarce. The intrinsic anti-oxidative properties and therapeutic potential for bone defects of metal-phenolic networks(MPNs)have provided a potential solution to this. Herein, we have developed a protocatechualdehyde + zinc ion(PCA+Zn^(Ⅱ)) MPN coating on a thermoplastic polyurethane membrane with a one-pot method to fabricate a new-type of periosteum with meritorious biocompatibility and abilities of modulating oxidative stress condition and promoting osteogenesis and mineralization for better bone regeneration, which has shown to be a promising strategy for constructing artificial periosteum with various MPNs.

关 键 词：Metal-phenolic networks Surface modification PERIOSTEUM Oxidative stress MINERALIZATION 

分 类 号：TQ317[化学工程—高聚物工业] R318.08[医药卫生—生物医学工程]