茵陈洗药泡浴联合间歇性蓝光照射治疗足月儿病理性黄疸疗效及对心肌、肝功能的影响  

Clinical Effect of Yinchen Bubble Bath Combined with Intermittent Blue Light Exposure in the Treatment of Pathological Jaundice in Term Infants and Its Influence on Cardiac Muscle and Liver Function

作　　者：刘培臣 李文松 陈永美 LIU Peichen;LI Wensong;CHEN Yongmei(Qingdao City Jiaozhou Central Hospital,Qingdao 266300,China)

机构地区：[1]青岛市胶州中心医院,山东青岛266300

出　　处：《西部中医药》2022年第5期136-139,共4页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨茵陈洗药泡浴联合间歇性蓝光照射治疗足月儿病理性黄疸疗效及对患儿心肌、肝功能的影响。方法:将足月病理性黄疸患儿92例随机分为两组各46例,对照组采用间歇性蓝光照射治疗,观察组采用自拟组方茵陈洗药泡浴联合间歇性蓝光照射治疗,治疗7天后比较两组临床疗效、心肌酶谱、肝功能指标及不良反应发生率。结果:观察组总有效率为93.48%,高于对照组的73.91%(P<0.05);观察组治疗后血清乳酸脱氢酶(lactate dehydrogenase,LDH)、磷酸肌酸激酶(creatine kinase,CK)、磷酸肌酸激酶同工酶(creatine kinase-MB,CK-MB)水平分别为(159.63±9.27)U/L、(122.38±5.70)U/L、(30.83±4.34)U/L,均分别低于对照组的(193.14±9.24)U/L、(164.35±5.44)U/L、(43.43±5.69)U/L(P<0.05);观察组治疗后血清总胆红素(total bilirubin,TBIL)、直接胆红素(serum direct bilirubin,DBIL)、门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、丙氨酸转移酶(alanine aminotransferase,ALT)水平分别为(115.75±11.03)μmol/L、(6.07±1.61)μmol/L、(14.78±2.61)U/L、(24.18±5.76)U/L,均分别低于对照组的(159.34±16.07)μmol/L、(10.11±2.33)μmol/L、(17.44±13.21)U/L、(31.84±10.28)U/L(P<0.05)。不良反应发生率两组比较差异无统计学意义(P>0.05)。结论:茵陈洗药泡浴联合间歇性蓝光照射能改善患儿血清胆红素水平,降低黄疸对心肌和肝功能的损伤,且安全可靠,疗效优于单纯间歇性蓝光照射治疗。Objective:To discuss clinical effects of Yinchen bubble bath combined with intermittent blue light exposure in treating pathological jaundice in term infants and its influence on cardiac muscle and liver function.Methods:All 92 term infants with pathological jaundice were randomized into two groups,with 46 cases in each group,the control group was treated by intermittent blue light exposure,the observation group by selfmade Yinchen bubble bath and intermittent blue light exposure,to compare clinical effects,myocardial enzyme,the indexes of liver function and the incidence of adverse reaction between both groups after they were treated for seven days.Results:Total effective rate of the observation group was 93.48%,higher than 73.91% of the control group(P<0.05);the levels of LDH,CK,CK-MB of the observation group were(159.63±9.27)U/L,(122.38±5.70)U/L and(30.83±4.34)U/Lafter treating,respectively lower than(193.14±9.24)U/L,(164.35±5.44)U/Land(43.43±5.69)U/L of the control group(P<0.05);the levels of TBIL,DBIL,AST,ALT of the observation group after treating were(115.75±11.03)μmol/L,(6.07±1.61)μmol/L,(14.78±2.61)U/L and(24.18±5.76)U/L,lower than(159.34±16.07)μmol/L,(10.11±2.33)μmol/L,(17.44±13.21) U/L and(31.84±10.28)U/L of the control group(P<0.05).The difference had no statistical meaning in the incidence of adverse reactions between both groups(P>0.05).Conclusion:Yinchen bubble bath and intermittent blue light exposure could improve the levels of serum bilirubin,decrease the injury of jaundice to myocardium and liver function,which is safe and reliable,clinical effects are superior to these of single intermittent blue light exposure.

关 键 词：病理性黄疸 心肌酶谱 肝功能 临床疗效 茵陈洗药泡浴方 间歇性蓝光照射 

分 类 号：R244.9[医药卫生—针灸推拿学]