Sequence motifs and prediction model of GBE editing outcomes based on target library analysis and machine learning  

作　　者：Bo Li Ya-Qiu Li Dongdong Zhao Jie Yang Yan-He Ma Chang-Hao Bi Xue-Li Zhang 

机构地区：[1]Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Key Laboratory of Systems Microbial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China [4]National Technology Innovation Center of Synthetic Biology,Tianjin 300308,China

出　　处：《Journal of Genetics and Genomics》2022年第3期254-257,共4页遗传学报（英文版）

基　　金：financially supported by the National Key Research and Development Program of China (2018YFA0903700);the National Natural Science Foundation of China (31861143019, 31770105, 32001041);a Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-KJGG-001);Tianjin Natural Science Foundation (20JCYBJC00310)。

摘　　要：Base editor techniques were developed for precise base conversion without requiring double-stranded DNA breaks(DSBs) or an editing template(Komor et al., 2016;Nishida et al., 2016).

关 键 词：PREDICTION EDITOR 

分 类 号：Q811.4[生物学—生物工程]